Objective To investigate the effect of comprehensive intervention on nervous development and timeliness of intervention for high risk infant with brain damage. Methods High risk infant with brain damage were divided into intervention and non-intervention groups according to compliance principle.The intervention groups were divided into intervention group of neonatal period(group A),intervention group of infancy period(group B) and intervention group of early childhood(group C) according to the different intervention time,while normal infants born in the same period selected as the control group(group E).The differences of movement,intelligence and neurodevelopment outcomes were analyzed. Results Except the NBNA score of group A was less than that of group E in the first week,there were similar with the levels of movement,intelligence and neurodevelopment outcomes between group A and group E.Evaluations of motor development,ratios of low intelligence and cerebral palsy were indicated that the effect of intervention group was better than non-intervention group(group D),the results of group A and group B were also better than those in group C(P<0.05). Conclusion Brain damage can lead to damage of movement,intelligent and neurodevelopment of infant to a certain extent.Comprehensive intervention have the improving results and the earlier is better.