Objective To explore the effect and adverse reaction of using clonidine sustained release tablets in the treatment of tourette syndrome (TS). Methods Total 110 cases of children with TS were randomly selected into treatment group and control group,55 cases in each group.Treatment group took only clonidine sustained release tablets.Control Group took haloperidol add the same dose of artane.The efficacy and adverse reactions of the two groups of children were compared and analyzed within 12 weeks. Results There was no significant difference between the treatment group and the control group in clinical curative (χ²=0.267P>0.05),but the safety of the former group was significantly higher than the latter. Conclusion Clonidine sustained release tablets can effectively improve the movement of children with tourette syndrome,vocal tics and combined injury.Its adverse reactions are obviously less and milder compared with haloperidol add the same dose of artane.