Changes of nuclear factor-kappa B and parvalbumin positive neurons in hippocampal CA1 region in VPA autism rats.

YI Ming-ji; SUN Ji-lian; CHEN Lei; LI Yin; FENG Xue-ying.

doi:10.11852/zgetbjzz2014-22-12-12

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Chinese Journal of Child Health Care ›› 2014, Vol. 22 ›› Issue (12) : 1271-1273. DOI: 10.11852/zgetbjzz2014-22-12-12

Changes of nuclear factor-kappa B and parvalbumin positive neurons in hippocampal CA1 region in VPA autism rats.

YI Ming-ji¹,SUN Ji-lian²,CHEN Lei³,LI Yin⁴,FENG Xue-ying¹.

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Abstract

Objective To establish the animal model of autism and explore pathogenesis of autism by observation of changes of nuclear factor-kappa B (NF-κB) and parvalbumin(PV) positive neurons in hippocampal CA1 region and to provide theoretical evidence for the therapeutic schedule of autism. Methods Animal model of autism was obtained as Schneider showed.The immunohistochemistry methods and image analysis were used to examine the number of NF-κB,and PV positive neurons in hippocampal CA1 region in autism model rats and the normal rats. Results The number of NF-κB positive neurons in the hippocampal CA1 region of the autism model rats was more than that of the normal rats(4.67±1.56 vs 3.00±1.54,t=2.639,P=0.015).The number of PV positive neurons in the hippocampal CA1 region of the autism model rats was more than that of the normal rats (5.33±0.99 vs 2.83±1.27,t=5.378,P=0.000). Conclusion The occurrence of autism may be related to the changes of NF-κB and PV in hippocampal CA1 region.

Key words

autism spectrum disorder / nuclear factor-kappa B / parvalbumin / valproic acid / rats

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YI Ming-ji,SUN Ji-lian,CHEN Lei,LI Yin,FENG Xue-ying.. Changes of nuclear factor-kappa B and parvalbumin positive neurons in hippocampal CA1 region in VPA autism rats.[J]. Chinese Journal of Child Health Care. 2014, 22(12): 1271-1273 https://doi.org/10.11852/zgetbjzz2014-22-12-12

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