Objective To understand the prevalence of common disease among the Han nationality pupils aged 7~18 years old in Karamay,and to provide the basis for improvment of the health condition of the region's pupils. Methods The test for 2 500 pupils aged 7 to 18 was in strict accordance with the requirements of 2010 National Student Physical Health Survey,including height,weight,vision,dental caries and other indicators,and the test results were analyzed statistically. Results In 2012,the prevalence of low vision among the Han nationality pupils in Karamay city was 50.72%;The prevalence of dental caries was 33.92%; obesity rate was 11.04%; malnutrition was 5.24%.Grade,gender,urban-rural differences were statistically significant (P<0.01). Conclusion The prevalence rate of common disease among the Han nationality pupils in karamay is not optimistic,family,school,community should strengthen prevention and control of common diseases.