Objective To study the relationship between the nutrition intake and weight growth velocity (WGV) of very-low-birth-weight (VLBW) infants during hospitalization. Methods A retrospective investigation was conducted in hospitalized VLBW infants in Shenzhen Women and Children's Hospital from 2011 to 2012,and the clinical characters and nutritional data were collected.The infants were divided into 3 groups according to the WGV,including low WGV group,medial WGV group and high WGV group.Then,the nutritional status were compared among the three groups. Results In the 147 VLBW infants,the medians of WGV and inpatient time were 12.77 g/(kg·d) and 48 days,respectively.Compared with low WGV group,the inpatient time,the time to achieve full enteral nutrition and the time to begin amino acid administration were lower than those in high and medial WGV groups.Dosage of carbohydrates,lipids and protein showed a decreasing trend in day 7,14,21 and 28 after the birth of VLBW infants. Conclusions The WGV of VLBW infants is associated with nutrition intake and inpatient time.Therefore,it is useful for weight gain in VLBW infants by enhancing enteral and parenteral nutrition and reducing the inpatient time.