Objective To explore the effects of prenatal vibration stress in different gestational time points on the spatial learning and memory in rats. Methods The Sprague-Dawley (SD) pregnant rats were vibrated strong and weak alternately in 1~7 d,8~14 d,15~21 d of gestation period,and the offspring was tested in Barnes maze to identify their spatial learning and memory,the difference of each group then compared. Results Learning process:1)The journey of exploration:It was higher than control group during early pregnancy group was in 4 d,during middle pregnancy group in 1d and during late pregnancy group in 1d;It was lower than control group during late pregnancy group in 2 and 3 d (P＜0.05);2)The average speed of exploration:It was lower than control group during early pregnancy group in 2 d,during middle pregnancy group in 1 d and 2 d,during late pregnancy group in 1,2,3,7,8 d (P＜0.05);3)The time of exploring errors holes:It was higher than control group during early pregnancy group in 1,2,4,7,8 d,during middle pregnancy group in 3,4,5,8d;It was lower than control group during late pregnancy group in 2,6 d (P＜0.05);4)The latency of exploring target hole:It was higher than control group during middle pregnancy group in 5 d (P＜0.05).Memory process:The time of exploring errors holes was higher during early pregnancy group(Mann-Whitney U=43.00,P=0.000);The journey of exploration (Mann-Whitney U=150.00),the average speed of exploring (Mann-Whitney U=150.00) and the time of exploring errors holes (Mann-Whitney U=164.50) were lower during late pregnancy group(P<0.05 or <0.01). Conclusion The vibration stress in early pregnancy group may damage the spatial learning and memory ability,and it may promote the spatial learning and memory ability in the late pregnancy group; but the vibration stress in mid pregnancy group only damage the spatial learning ability.
Key words
prenatal vibration stress /
Barnes maze /
spatial learning and memory
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 林崇德,杨志良,黄希庭.心理学大辞典[M].上海教育出版社,2004:1575.
[2] Buss C,Davis EP,Hobel CJ,et al.Maternal pregnancy-specific anxiety is associated with child executive function at 6~9 years age[J].Stress,2011,14(6):665-676.
[3] Emack J,Kostaki A,Walker CD,et al.Chronic maternal stress affects growth,behaviour and hypothalamo-pituitary-adrenal function in juvenile offspring[J].Hormones andBehavior,2008,54(4):514-520.
[4] Wilson CA,Terry AV Jr.Variable maternal stress in rats alters locomotor activity,social behavior,and recognition memory in the adult offspring[J].Pharmacol Biochem Behav,2013,104:47-61.
[5] 童建斌,刘丹,黄菊芳,等,不同时期的母鼠妊娠期应激对子代成年后海马的影响[J].中国现代医学杂志,2004,14(11):81-83.
[6] Schwabe L,Bohbot VD,Wolf OT.Prenatal stress changes learning strategies in adulthood[J].Hippocampus,2012,22(11):2136-2143.
[7] Kapoor A,Kostaki A,Janus C,et al.The effects of prenatal stress on learning in adult offspring is dependent on the timing of the stressor[J].Behav Brain Res,2009,197(1):144-149.
[8] Sahu SS,Madhyastha S,Rao GM.Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na(+),K(+)-ATPase activity[J].Pharmacol Biochem Behav,2013,103(3):520-525.
[9] 张先庚,杨宇琦,李世通,等.模拟地震实验深化“恐伤肾”的研究[J].四川中医,2008,26(12):27-28.
[10] Li X,Risbrough VB,Cates-Gatto C,et al.Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior,learning,and memory in mice[J].Neuropharmacology,2013,70:156-167.
[11] Schwabe L,Wolf OT,Oitzl MS.Memory formation under stress:Quantity and quality[J].Neurosci Biobehav,2010,34(4):584-591.
[12] 毛凤霞,姚梅玲,产前束缚应激对大鼠子代的影响[J].中国妇幼保健,2008,23(26):3720-3721.
[13] Yang J,Han H,Cao J,et al.Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring[J].Hippocampus,2006,16(5):431-436.
PDF(721 KB)
