Objective To observe the early continued exposure to music environment on blood pressure and the incidence of adverse cardiovascular events of rats in adulthood. Methods 20 male SD rats was exposed to music (Mozart 《G minor Symphony No.fortieth》) in 24h after birth,the same age SD rats as control group,keeping the same conditions but without music.In 5~8 weeks,blood pressure was monitored by noninvasive method daily.Afer 8 weeks,rats were sacrificed,aortic endothelial morphology was observed by scanning electron microscope and angiotensin II (Ang II),C reactive protein (CRP),plasminogen activator inhibitor -1 (PAI-1),plasma brain natriuretic peptide (BNP) in serum was determined by ELISA. Results The rats of music group and control had no significant differences in weight and heart rate.Systolic and mean arterial pressure decreased in rats of music group,but without statistical significance.The aortic endothelial morphology of rats of music group was better,with no fiber attachment;that of control group was also normal,but some of the cell connection was missing,and with more endometrial attachment.The serum CRP,PAI-1 of rats of music group decreased significantly (P<0.05).Ang Ⅱ,BNP had a decreasing tendency,but no significant differences were found between the two groups. Conclusion The early continuous exposure to music environment demonstrated beneficial effects on the cardiovascular system in developing rats.The decreasement of blood pressure of adult rats is not very significant,but its propensity of occurrence of adverse cardiovascular events had been greatly reduced.
Key words
music /
risk of adverse cardiovascular events /
blood pressure
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References
[1] Nombela C,Hughes LE,Owen AM,et al.Into the groove:Can rhythm influence Parkinson's disease?[J].Neurosci Biobehav Rev,2013,37(10 Pt 2):2564-2570.
[2] Bernardi L,Porta C,Casucci G,et al.Dynamic interactions between musical,cardiovascular,and cerebral rhythms in humans[J].Circulation,2009;119(25):3171-3180.
[3] Sutoo D,Akiyama K.Music improves dopaminergic neurotransmission:demonstration based on the effect of music on blood pressure regulation[J].Brain Research,2004,1016 (2):255-262.
[4] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志,2011,39(7):579-616.
[5] Chung DY,Sim YB,Park KT,et al.Spectral analysis of fetal heart rate variability as a predictor of intrapartum fetal distress[J].International J of Gynecol & Obstet,2001,73(2):109-116.
[6] Feng XU,Rui CAI,Jinghong XU,et al.Early music exposure modifies GluR2 protein expression in rat auditory cortex and anterior cingulate cortex[J].Neuroscience Letters,2007,420(2):179-183.
[7] Chiu WC,Juang JM,Chang SN,et al.Angiotensin II regulates the LARG/RhoA/MYPT1 axis in rat vascular smooth muscle in vitro[J].Acta Pharmacol Sin,2012,33(12):1502-1510.
[8] Eapen DJ,Manocha P,Patel RS,et al.Aggregate risk score based on markers of inflammation,cell stress,and coagulation is an independent predictor of adverse cardiovascular outcomes[J].J Am Coll Cardiol,2013,62(4):329-337.
[9] Meijer CA,Le Haen PA,van Dijk RA,and et al.Activator protein-1 (AP-1) signalling in human atherosclerosis:results of a systematic evaluation and intervention study[J].Clin Sci (Lond),2012,122(9):421-428.
[10] Troughton R,Michael Felker G,Januzzi JL.Natriuretic peptide-guided heart failure management[J].Eur Heart J,2014,35(1):16-24.
[11] Wang TJ,Gona P,Martin G,et al.Larson multiple biomarkers and the risk of incident hypertension[J].Hypertension,2007,49(3):432-438.
[12] Carty DM,Schiffer E,Delles C.Proteomics in hypertension[J].Journal of Human Hypertension,2013,27(4):211-216.
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