Objective To investigate macrosomia inflammatory indexes in vivo tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) level and the correlation. Methods As from January to December 2012, 30 cases of normal weight newborn babies and 60 cases of macrosomiain were Maternal and Child Health Care Hospital of Shaanxi investigated.According to the pregnant mother BMI, macrosomia were further divided into cases of mother obesity and cases of mother normal weight.3 mL neonatal umbilical cord blood was taken from baby.After the centrifugal, serum was taken out and hs-CRP and TNF-α were tested with enzyme-linked immunoassay. Results Levels of hs-CRP in every two groups were statistically significant (P<0.05), and gradually increased in normal newborns, huge children of normal weight mothers, huge child of obesity mothers three groups difference.TNF-α in the three groups showed no significant difference between the newborn (P>0.05).Birth weight and hs-CRP was positively correlated (r=0.417, P＜0.05).Birth weight and TNF-α was no significant correlation (P>0.05). Conclusion Macrosomia has low-grade inflammation, hs-CRP and birth weight has positively correlation.
Key words
macrosomia /
tumor necrosis factor-α /
high-sensitivity C-reactive protein
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