Objective To investigate the epidemiological characteristics of measles in Hubei Province, and to provide a scientific basis for measles elimination strategies. Methods By descriptive epidemiology research methods, measles cases reported in Hubei Province 2006-2012 were analyzed to explore factors influencing the epidemiological characteristics of measles in Hubei Province. Results CCP monitoring reporting system reported 604 cases of suspected measles in 7 years, 15 388 cases were diagnosed measles cases, 2 520 cases of laboratory diagnosis, 12 868 cases of clinical diagnosis, 12 156 cases were reported under 15 years old;Annual incidence rates were 4.02/10⁵, 6.42/10⁵, 6.88/10⁵ and 7.01/10⁵ in 2006-2009, showing the state of the overall height of sporadic;Different months had occurred throughout the year, which was high in April and May, the peak of incidence in May;Sex ratio 1.74∶1;Larger proportion of small age group, the minimum age was 24 d;In the vaccination history from 2009 to 2012, case without history of immune were 30.29%, 29.41%, 33.72%, 66.83% respectively in monitoring data;8 634 cases were scattered children, accounting for 56.10%;2 482 cases were students, accounting for 16.13%. Conclusions Improving vaccination rates for measles vaccine, the success rate of immunization and leak replant are the key measures in reducing or eliminating the incidence of measles, strengthen routine immunization in young age and immune response strategies for measles immunization program in Hubei province is especially important.