Objective To explore the temperament characteristics of brain injury high-risk infants, and to offer help for early intervention and rearing style for those baby. Methods In child care clinics, 150 cases of 1~4 months infants with the high-risk factors of brain development before birth or birth were randomly selected, 150 healthy children of the same age as control group, raising people of two group were investigated by the Early Infant Temperament Questionnaire developed by Cary and others, the nine dimensions scores were analyzed. Results Scores of high-risk infants group in approach and withdrawal, response intensity two dimensions were significantly higher than normal group (P<0.05), while scores of the rhythmic, persistence, mood and response threshold four dimensions were significantly lower than normal group (P<0.05), the remaining three dimension scores had no statistical differences.It prompted that high-risk infants were lack of rhythmic, timid around strangers, response strongly, poor persistence, more depressed and sensitive to things around them.From the perspective of the composition of temperament type, the number of two groups of five types of temperament had significant differences (P<0.001), There were more performance for somewhat difficult parenting temperament among high-risk infants. Conclusions The supporter in early intervention of brain injury high-risk infants should understand its temperament characteristics as early as possible, and targeted way of individualized education according to their characteristics, will be better for their rehabilitation.