Objective To examine the abnormal white matter microstructure of acdism spectrum disorders (ASDs) children of school age via Diffusion Tensor Imaging,so as to investigate the possible evidence of dysplasia of neurodevelopment. Methods 14 ASDs boys of school age and 7 age,IQ and handedness matched typically developing controls were examined by diffusion tensor imaging (DTI),the fractional anisotropy (FA) and mean diffusivity (MD) values were compared between two groups through voxel-based analysis. Results Compare to TD group,the FA value was increased in the left temporal gyrus,left frontal gyrus,left occipital gyrus,hippocampus and thalamus,and the MD value was decreased in the left calcarine fissure,bilateral fusiform gyrus,right temporal gyrus,right frontal gyrus,right occipital gyrus,left parahippocampus gyrus,posterior cingulate cortex and left lingual gyrus in ASDs group. Conclusion Abnormal white matter microstructure widely spread over the brain of high-functional autism of school age.
Key words
high-functional autism /
diffusion tensor imaging /
voxel-based analyze
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