Objective To study the effect of vitamin D supplementation in early preterm infants on the immune function. Methords The 158 preterm infants from Cangzhou People's Hospital were selected in the study,and were divided into the large for gestational age group and small for gestational age group.Each group was randomly divided into control group and experimental group.The control group was given formula feeding.The experimental group on the basis of the control group,was fed vitamin D intake 400 U/d from 3rd to 10th day after birth.Serum 25-(OH) D,IL-2 and IgG,IgA,IgM were tested before and after the experiment,and vitamin D toxicity was observed. Results It was high prevalence of moderately severe vitamin D deficiency in preterm infants.Serum 25-(OH) D level of experimental group was significantly higher than that of the control group(P＜0.05).In the small and large for gestational age group,vitamin D supplementation of 400 U/d respectively increased mean 25-(OH)D levels from 23.556 nmol/L,27.771 nmol/L at birth to 27.423 nmol/L,32.198 nmol/L at discharge.With the development of 25-(OH) D level,IL-2 level increased significantly,experimental group had significant difference compared with the control (P<0.05),while IgG,IgA,IgM had no significant change (P>0.05). Conclusions Early vitamin D supplementation can improve immunity of premature infants.Further research is required on the effect on humoral immunity.
Key words
preterm infants /
vitamin D /
supplement /
early neonatal /
immunologic function
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References
[1] 周建烈,陈炜俊,吴光驰.维生素D补充的研究进展[J].中华儿科杂志,2009,47(9):714-715.
[2] 王丹华,刘喜红,丁宗一.早产/低出生体重儿喂养建议[J].中国儿童保健杂志,2011,19(9):868-870.
[3] Dall'Agnola A,Beghini L.Post-discharge supplementation of vitamins and minerals for preterm neonates[J].Early Hum Dev,2009,85(10S):27-29.
[4] Hanson C,Armas L,Lyden E,et al.Vitamin D status and associations in newborn formula-fed infants during initial hospitalization[J].J Am Diet Assoc,2011,111(12):1836-1843.
[5] 李扬方,蔡芝兰,潘晓洁,等.新生儿HIE、感染性疾病及早产儿IL-2、IL-6检测[J].小儿急救医学,2003,10(2):96-97.
[6] Gorman S,Judge MA,Hart PH.Gene regulation by 1,25-dihydroxyvitamin D3 in CD4+CD25+ cells is enabled by IL-2[J].J Invest Dermatol,2010,130(10):2368-2376.
[7] Matilainen JM,Räsänen A,Gynther P,et al.The genes encoding cytokines IL-2,IL-10 and IL-12B are primary 1alpha,25(OH)2D3 target genes[J].J Steroid Biochem Mol Biol,2010,121(1-2):142-145.
[8] Yusupov E,Ling M,Pollack S,et al.Vitamin d and serum cytokines in a randomized clinical trial[J].Int J Endocrinol,2010,12:3050-3054.
[9] 杨月亮,李振玲.维生素D与免疫功能关系分析[J].滨州医学院学报,2003,26(2):93-94.
[10] HolmØy T,Lossius A,Gundersen TE,et al.Intrathecal levels of vitamin D and IgG in multiple sclerosis[J].Acta Neurol Scand,2012,125(6):e28-31.
[11] 李培,祁晓萍.1,25-二羟维生素D3及其类似物对免疫系统的调节作用[J].医学研究生学报,2007,20(3):298-301.
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