Objective To observe the health-related quality of life(HRQOL) of children with recurrent respiratory tract infection (RRTI)simultaneously inoculated by pneumococcal vaccine combined with influenza vaccine. Methods A total of 278 cases RRTI were randomly divided into two groups.The control group (n=135 patients) was used with placebo only while the vaccine group (n=143 patients) was simultaneously inoculated with pneumococcal vaccination combined with influenza vaccine.The PedsQL^TM 4.0 scores and clinical indicators were observed in each group before the inoculations; 14 months and 26 months after the inoculation. Results There were no significant differences in the number of cases, gender, age, duration and SES score in the two groups (P>0.05);The incidence of upper and lower respiratory tract infection, respiratory diseases caused by the frequency of fever, the number of days of antibiotic use and total cost of treatment in the vaccine group were significantly less than those of the control group (P<0.05);The PedsQL^TM 4.0 score showed no significant difference in both groups(P>0.05) before the inoculation;Each dimension of the quality of life of the vaccine group significantly increased as inoculation time extended (P<0.05), while those of control group showed no significant difference (P>0.05). Conclusion Combination of inoculation of pneumococcal vaccine and influenza vaccine can effectively improve the HRQOL of RRTI children as well as the PedsQL^TM 4.0 score and it should be highly recommended clinically.