Objective To study the brain biochemical metabolism changes of infantile spasms through hydrogen proton magnetic resonance spectroscopy(1HMRS). Methods A total of 40 cases of infantile spasms and 10 age-matched normal infants were performed brain 1.5T MRI and multi-voxel 1H-MRS exminations, volume of interest (VOI) included thalamus, basal ganglia, temporal lobe, the signal intensities of N-acetylaspartate(NAA), creatine+phosphocreatine (Cr), choline-containig compounds(Cho) were obtained, the ratios of NAA/Cho+Cr, Cho/Cr, and NAA/Cr were set into comparison bilaterally between the patients and controls. Results 1)The ratios of NAA/Cho+Cr, NAA/Cho, NAA/Cr were lower than normal group(P＜0.01), and the ratios of Cho/Cr were increased than normal group, the difference were statistically significant(P all ＜0.01).2)High lac peak could be seen in areas of lesions often. Conclusion The 1H-MRS can noninvasively evaluate changes of cerebral metabolism in infantile spasms.
Key words
infantile spasms /
hydrogen proton magnetic resonance spectroscopy /
volume of interest /
biochemical metabolism
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