目的 分析广州地区25 295名儿童维生素D营养状况与年龄、季节的关系。 方法 采用酶联免疫法检测25-羟基维生素D[25-(OH)D]水平,收集2012年全年广州市妇女儿童医疗中心25 295例0~16周岁健康儿童25-(OH)D结果,维生素D营养状况以血清水平判断:维生素D严重缺乏(<12.5 nmol/L)、维生素D缺乏(12.5~37.5 nmol/L)、维生素D不足(37.5~50.0 nmol/L),分别各年龄组及各月份应用SPSS 17.0统计软件进行分析。结果 2012年广州地区25 295例儿童25-(OH)D平均水平72.41 nmol/L,无性别差异;无维生素D严重缺乏病例;25-(OH)D<50 nmol/L的比例为13.22%。儿童25-(OH)D水平随年龄的增长而降低,维生素D的缺乏和不足与年龄呈正比;2012年1月份为全年最低水平,1~7月份25-(OH)D水平逐月上升, 8、9月份达到全年峰值,10~12月份逐月下降;各月份维生素D缺乏和不足的比例在1月份为全年最高,全年最低值在9月份。 结论广州地区在冬春季节儿童维生素D营养水平较低,3周岁以上的儿童维生素D营养缺乏较严重。

Objective To analyze vitamin D nutritional status among 25 295 children in Guangzhou area and investigate its correlation with age and season. Methods The serum samples of healthy children from Guangzhou Women and Children's Medical Center in 2012 were tested.Serum 25-hydroxyvitamin D[25-(OH)D] concentration was determined by ELISA kits.Serum Vitamin D status was classified into 3 groups according to its serum 25-(OH)D levels,severe deficiency(<12.5 nmol/L),deficiency(12.5~37.5 nmol/L) and insufficiency(37.5~50.0 nmol/L).Statistical analysis were done with SPSS 17.0 software. Results Totally,25 295 children samples were detected in 2012.The average serum 25-(OH)D concentration was 72.41 nmol/L.No significant correlation was found between the serum 25-(OH)D concentration and gender.Severe deficiency case was not found.The vitamin D concentration <50 nmol/L was 13.22%.The 25-(OH)D concentration decreased with age.The lowest concentration of vitamin D was found in Jan 2012.Then it increased gradually from Jan.to July,peaking in Aug.and Sep.and slow declined.Meanwhile,he vitamin D deficiency and insufficiency rate was peaking in Jan.and lowest in Sep..Conclusion The vitamin D concentration is lower in autumn and winter.The vitamin D nutritional status of children over 3 years old in Guangzhou is deficiency.