婴儿乳糖酶活性与肠道菌群对其体重增长的影响
- 颜引妹1,张燕1,颜雨静2,唐华1,白玲1,陆纯1,汪科1
作者信息
+
Effect of lactase activity and intestinal microflora on infant's weight gain
- YAN Yin-mei1,ZHANG Yan1,YAN Yu-jing2,TANG Hua1,BAI Ling1,LU Chun1,WANG Ke1
Author information
+
文章历史
+
摘要
目的 探讨婴儿乳糖酶活性与肠道菌群对其体重增长的影响,及乳糖酶和益生菌治疗后对其体重增长速率的变化。 方法 从2011年5月-2012年8月期间,从门诊随机收集42 d的体检婴儿共97例(男52,女45),实验组为体弱儿:满月体重增长不足600 g的婴儿共58(男33,女25)例;对照组为体重增长超过600 g家长自愿参加的正常婴儿32例(男19,女13)例,予尿半乳糖测定和粪肠道菌群测定。对实验组给予乳糖酶与益生菌治疗,观察治疗后一月体重增长的变化。结果 实验组尿半乳糖测定阳性率与对照组比较明显增高(P＜0.005),肠道菌群调查显示有失调(P＜0.01)。提示实验组存在乳糖酶活性低下和肠道菌群紊乱;实验组治疗1月后肠道菌群均＞10∶1,体重增长值与对照组比较差异无统计学意义(P＞0.05),说明其肠道功能恢复,体重增长速度跟上了对照组。 结论体弱儿体重增长缓慢的原因之一是乳糖酶活性低下和肠道菌群失调,补充乳糖酶与益生菌是有效的。
Abstract
Objective To investigate the effect of lactase activity and intestinal microflora on infant's weight gain,and the change of weight increasing rate after lactase and probiotics therapy. Methods From 2011 June to 2012 August,97 cases of infants (52 males,45 females) under 42 days were randomly collected from outpatients section.The experimental group were 58 cases of frail infants (33 males,25 females) whose weight increase in the first month of birth were less than 600 g; The control group were 32 cases of normal infants (19 males,13 females) volunteered by parents.They were given urinary galactose and fecal intestinal flora test.The experimental group was given the lactase and probiotics treatment and their weight increase were observed one month later. Results The positive rate of urinary galactose test for experimental group was much higher than control group (P<0.005) and intestinal flora showed disorder (P<0.01),indicating that experimental group had low lactase activity and intestinal flora disturbance.After a month of therapy,all the infants in experimental group had intestinal flora>10∶1,and the increase of weight had no significant difference with control group (P>0.05).This was the evidence of their recovery of intestinal function and their rates of weight increase keep up with the control group.Therefore,the therapy of treating frail infants with lactase and double probiotics was proved to be effective. Conclusions One of the reasons of low weight increase rate of frail infants is the low lactase activity and intestinal flora imbalance.It is effective to supple lactase and probiotics.
关键词
乳糖酶活性 / 肠道菌群 / 体重增长速率 / 乳糖酶 / 益生菌
Key words
lactase activity / intestinal flora / growth rate / lactase / probiotics
{{custom_sec.title}}
{{custom_sec.title}}
参考文献
[1] Richard J,Grand MD,Robert K,et al.Lactose malabsorption[J].Current Treatment Options in Gastroenterology,2008,1(1):19-25.
[2] Campbell AK,Matthews SB,Vassel N,et al.Bacterial metabolic 'toxins':a new mechanism for lactose and food intolerance,and irritable bowel syndrome[J].Toxicology,2010,278(3):268-276.
[3] Hutyra T,Iwańczak B.Determination of milk and diary products consumption and their connection with lactose malabsorption or lactose intolerance in selected disorders of the alimentary tract in children[J].Polski Merkuriusz Lekarski:Organ Polskiego Towarzystwa Lekarskiego,2009,26(152):110-116.
[4] Heyman MB,Committee on Nutrition.Lactose intolerance in infants,children,and adolescents[J].Pediatrics,2006,118(3):1279-1286.
[5] Liverpool UK,Chong CK,Bunn J,et al.Lactose intolerance in infants:harder to investigate now following discontinuation of Clinitest[J].P Arch Dis Child,2010,96(6):611-615.
[6] Novillo A,Peralta D,Dima G,et al.Frequency of bacterial overgrowth in patients with clinical lactose intolerance[J].Acta Gastroenterol,Latinoam,2010,40(3):221-224.
[7] He T,Priebe MG,Zhong Y,et al.Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects[J].Appl Microbiol,2008,104(2):595-604.
[8] Zhao J,Fox M,Cong Y,et al.Lactose intolerance in patients with chronic functional diarrhoea:the role of small intestinal bacterial overgrowth[J].Alimentary Pharmacology & Therapeutics,2010,31(8):892-900.
[9] Asma A,Michael D,Brent C,et al.Systematic review:effective management strategies for lactose intolerance[J].Annals of Internal Medicine,2010,152(12):797-803.
[10] Ibarra A,Acha R,Calleja MT,et al.Optimization and shelf life of a low-lactose yogurt with lactobacillus rhamnosus HN001[J].Dairy Sci,2012,95(7):3536-3548.
[11] Zhong Y,Priebe RJ,Vonk CY,et al.The role of colonic microbiota in lactose intolerance[J].Dig Dis Sci,2004,49:78-83.
[12] Shaukat A,Levitt BC,Taylor R,et al.Systematic review:Effective management strategies for lactose intolerance[J].Ann Intern Med,2010,152:797-803.
[13] Ospedale S,Perino A,Cabras S,et al.Lactose intolerance:a non-allergic disorder often managed by allergologists[J].Eur Ann Allergy Clin Immunol,2009,41(1):3-16.
[14] Hu X,Robin S,O'Connell S,et al.Engineering of a fungal beta-galactosidase to remove product inhibition by galactose[J].Appl Microbiol Biotechnol,2010,87(5):1773-1782.
[15] Ibrahim SA,Alazzeh AY,Awaisheh SS,et al.Enhancement of alpha- and beta-galactosidase activity in Lactobacillus reuteri by different metalions[J].Biol Trace Elem Res,2010,136(1):106-116.
[16] Almeida CC,Lorena SL,Pavan CR,et al.Beneficial effects of long-term consumption of a probiotic combination of Lactobacillus case Shirota and Bifidobacterium breve Yakult may persist after suspension of therapy in lactose-intolerant patients[J].Nutr Clin Pract,2012,27(2):247-251.
[2] Campbell AK,Matthews SB,Vassel N,et al.Bacterial metabolic 'toxins':a new mechanism for lactose and food intolerance,and irritable bowel syndrome[J].Toxicology,2010,278(3):268-276.
[3] Hutyra T,Iwańczak B.Determination of milk and diary products consumption and their connection with lactose malabsorption or lactose intolerance in selected disorders of the alimentary tract in children[J].Polski Merkuriusz Lekarski:Organ Polskiego Towarzystwa Lekarskiego,2009,26(152):110-116.
[4] Heyman MB,Committee on Nutrition.Lactose intolerance in infants,children,and adolescents[J].Pediatrics,2006,118(3):1279-1286.
[5] Liverpool UK,Chong CK,Bunn J,et al.Lactose intolerance in infants:harder to investigate now following discontinuation of Clinitest[J].P Arch Dis Child,2010,96(6):611-615.
[6] Novillo A,Peralta D,Dima G,et al.Frequency of bacterial overgrowth in patients with clinical lactose intolerance[J].Acta Gastroenterol,Latinoam,2010,40(3):221-224.
[7] He T,Priebe MG,Zhong Y,et al.Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects[J].Appl Microbiol,2008,104(2):595-604.
[8] Zhao J,Fox M,Cong Y,et al.Lactose intolerance in patients with chronic functional diarrhoea:the role of small intestinal bacterial overgrowth[J].Alimentary Pharmacology & Therapeutics,2010,31(8):892-900.
[9] Asma A,Michael D,Brent C,et al.Systematic review:effective management strategies for lactose intolerance[J].Annals of Internal Medicine,2010,152(12):797-803.
[10] Ibarra A,Acha R,Calleja MT,et al.Optimization and shelf life of a low-lactose yogurt with lactobacillus rhamnosus HN001[J].Dairy Sci,2012,95(7):3536-3548.
[11] Zhong Y,Priebe RJ,Vonk CY,et al.The role of colonic microbiota in lactose intolerance[J].Dig Dis Sci,2004,49:78-83.
[12] Shaukat A,Levitt BC,Taylor R,et al.Systematic review:Effective management strategies for lactose intolerance[J].Ann Intern Med,2010,152:797-803.
[13] Ospedale S,Perino A,Cabras S,et al.Lactose intolerance:a non-allergic disorder often managed by allergologists[J].Eur Ann Allergy Clin Immunol,2009,41(1):3-16.
[14] Hu X,Robin S,O'Connell S,et al.Engineering of a fungal beta-galactosidase to remove product inhibition by galactose[J].Appl Microbiol Biotechnol,2010,87(5):1773-1782.
[15] Ibrahim SA,Alazzeh AY,Awaisheh SS,et al.Enhancement of alpha- and beta-galactosidase activity in Lactobacillus reuteri by different metalions[J].Biol Trace Elem Res,2010,136(1):106-116.
[16] Almeida CC,Lorena SL,Pavan CR,et al.Beneficial effects of long-term consumption of a probiotic combination of Lactobacillus case Shirota and Bifidobacterium breve Yakult may persist after suspension of therapy in lactose-intolerant patients[J].Nutr Clin Pract,2012,27(2):247-251.
基金
江苏大学2012年医学临床科技发展基金项目(JLY20120021)
-
总访问量
今日访问
在线人数
扫一扫，关注本刊微信公众号
版权所有 © 《中国儿童保健杂志》编辑部
技术支持：北京玛格泰克科技发展有限公司
技术支持：北京玛格泰克科技发展有限公司
/
| 〈 |
|
〉 |