摘要
肠道菌群是一个复杂的生态系统,与宿主相互作用,影响宿主代谢及多种生理功能。研究发现,肠道菌群的改变可引发慢性炎症反应,进而导致肥胖、胰岛素抵抗等代谢失调。本文就肠道菌群与肥胖、胰岛素抵抗发生、发展的关系及部分机制进行综述。
关键词
{{custom_sec.title}}
{{custom_sec.title}}
参考文献
[1] Ogden CL,Carroll MD,Curtin LR,et al.Prevalence of overweight and obesityin the United States,1999-2004[J].JAMA,2006,295(13):1549-1555.
[2] Ogden CL,Carroll MD,Flegal KM.High body mass index for age among US children and adolescents,2003-2006[J].JAMA,2008,299(20):2401-2405.
[3] Ji CY,Cheng TO.Epidemic increase in overweight and obesity in Chinese children from 1985 to 2005[J].Int J Cardiol,2009,132(1):1-10.
[4] Qin J,Li R,Raes J,et al.A human gut microbial gene cata-logue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
[5] Ley RE,Turnbaugh PJ,Klein S,et al.Microbial ecology:human gut microbes associated with obesity[J].Nature,2006,444(7122):1022-1023.
[6] Ley RE,Backhed F,Turnbaugh P,et al.Obesity alters gut microbial ecology[J].Proc Natl Acad Sci,2005,102:11070-11075.
[7] Backhed F,Ding H,Wang T,et al.The gut microbiota as an environmental factor that regulates fat storage[J].Proc Natl Acad Sci,2004,101:15718-15723.
[8] Backhed F,Manchester JK,Semenkovich CF,et al.Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J].Proc Natl Acad Sci,2007,104(3):979-984.
[9] Atarashi K,Tanoue T,Shima T,et al.Induction of colonic regulatory T cells by indigenous Clostridium species[J].Science,331(6015):337-341.
[10] Reigstad CS,stergren Lundén G,Felin J,et al.Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota[J].PLoS ONE,2009,4(6):e5842-5848.
[11] Ding S,Chi MM,Scull BP,et al.High-fat diet:bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse[J].PLoS ONE,2010,5(8):e12191-12199.
[12] Cani PD,Delzenne NM.Role of gut microflora in the development of obesity and insulinresistance following high-fat diet feeding[J].Pathologie BiologieJan,2008,56:305-309.
[13] Cani PD,Neyrinck AM,Fava F,et al.Selective increases of bifidobacteria in gut microflora improves high-fat diet-induced diabetes in mice through a mechanism associated with endotoxemia[J].Diabetologia,2007,50(11):2374-2383.
[14] Amar J,Burcelin R,Ruidavets JB,et al.Energy intake is associated with endotoxemia in apparently healthy men[J].Am J Clin Nutr,2008,87:1219-1223.
[15] Ghanim H,Abuaysheh S,Sia CL,et al.Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat,high-carbohydrate meal:implications for insulin resistance[J].Diabetes Care,2009,32:2281-2287.
[16] Deopurkar R,Ghanim H,Friedman J,et al.Differential effects of cream,glucose,and orange juice on inflammation,endotoxin,and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3[J].Diabetes Care,2010,33:991-997.
[2] Ogden CL,Carroll MD,Flegal KM.High body mass index for age among US children and adolescents,2003-2006[J].JAMA,2008,299(20):2401-2405.
[3] Ji CY,Cheng TO.Epidemic increase in overweight and obesity in Chinese children from 1985 to 2005[J].Int J Cardiol,2009,132(1):1-10.
[4] Qin J,Li R,Raes J,et al.A human gut microbial gene cata-logue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
[5] Ley RE,Turnbaugh PJ,Klein S,et al.Microbial ecology:human gut microbes associated with obesity[J].Nature,2006,444(7122):1022-1023.
[6] Ley RE,Backhed F,Turnbaugh P,et al.Obesity alters gut microbial ecology[J].Proc Natl Acad Sci,2005,102:11070-11075.
[7] Backhed F,Ding H,Wang T,et al.The gut microbiota as an environmental factor that regulates fat storage[J].Proc Natl Acad Sci,2004,101:15718-15723.
[8] Backhed F,Manchester JK,Semenkovich CF,et al.Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J].Proc Natl Acad Sci,2007,104(3):979-984.
[9] Atarashi K,Tanoue T,Shima T,et al.Induction of colonic regulatory T cells by indigenous Clostridium species[J].Science,331(6015):337-341.
[10] Reigstad CS,stergren Lundén G,Felin J,et al.Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota[J].PLoS ONE,2009,4(6):e5842-5848.
[11] Ding S,Chi MM,Scull BP,et al.High-fat diet:bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse[J].PLoS ONE,2010,5(8):e12191-12199.
[12] Cani PD,Delzenne NM.Role of gut microflora in the development of obesity and insulinresistance following high-fat diet feeding[J].Pathologie BiologieJan,2008,56:305-309.
[13] Cani PD,Neyrinck AM,Fava F,et al.Selective increases of bifidobacteria in gut microflora improves high-fat diet-induced diabetes in mice through a mechanism associated with endotoxemia[J].Diabetologia,2007,50(11):2374-2383.
[14] Amar J,Burcelin R,Ruidavets JB,et al.Energy intake is associated with endotoxemia in apparently healthy men[J].Am J Clin Nutr,2008,87:1219-1223.
[15] Ghanim H,Abuaysheh S,Sia CL,et al.Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat,high-carbohydrate meal:implications for insulin resistance[J].Diabetes Care,2009,32:2281-2287.
[16] Deopurkar R,Ghanim H,Friedman J,et al.Differential effects of cream,glucose,and orange juice on inflammation,endotoxin,and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3[J].Diabetes Care,2010,33:991-997.
-
总访问量
今日访问
在线人数
扫一扫，关注本刊微信公众号
版权所有 © 《中国儿童保健杂志》编辑部
技术支持：北京玛格泰克科技发展有限公司
技术支持：北京玛格泰克科技发展有限公司
/
| 〈 |
|
〉 |