目的 研究兰州市5~13岁正常儿童和注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)合并睡眠障碍儿童及其血清中促睡眠肽(human delta sleep-inducing peptide,DSIP)的指标进行分析总结。以便实施早期干预治疗的措施。 方法 随机抽取兰州市5个小学和2个幼儿园,对5~13岁的1 100名儿童进行ADHD简化的康奈尔儿童行为量表及睡眠问题的问卷初筛调查,并进行评估打分确定多动指数(Conner's Abbreviated Symptom Questionnaire,ASQ)≥15分为疑似ADHD。由指定的专业技术医师根据美国精神病协会制定的诊断DSM-Ⅳ(1991)标准,进行鉴定确诊。最后测定样本血清DSIP等指标。 结果 1)ADHD组并存的睡眠问题明显高于正常组(P＜0.001),两者有明显的相关性;2)ADHD观察组和正常对照组两组血清中的DSIP 指标分别为:112.12±8.50;338.64±526.02;差异有统计学意义(P=0.019);3)对ASQ与DSIP、常见睡眠问题及学习成绩的相关性采用Pearson分析,结果发现:DSIP与 ASQ呈负相关(P＜0.001);睡眠问题越多的儿童ASQ就越高并且与儿童的学习成绩呈负相关(P＜0.001)。 结论 ADHD的儿童存在着血清DSIP分泌不足的情况,并存着不同程度的睡眠问题,影响学习成绩。

Objective Based on observations and investigations of associations among normal and attention deficit hyperactivity disorder (ADHD) children with sleep disorder aged 5~13,and related index of human delta sleep-inducing peptide(DSIP) level in blood serum.Then followed by an analysis and summary to explores ADHD's onset mechanism and prevention and treatment. Methods Random sampling of 1 100 children aged 5 to 13 were taken from five primary schools and two kindergartens in Lanzhou City for a Conner's Abbreviated Symptom Questionnaire (ASQ)and initial screening of sleep problem.Evaluation was thus made,with ≥15 marks of suspected ADHD.Designated specialists made a definite diagnosis in line with the DSM-IV (1991) standard.Blood serum tests on an empty stomach were given to both groups for DSIP levels. Results 1)The problem of sleep in ADHD group was remarkably significant(P＜0.001)and markedly associated with AOHO.2)DSIP was negatively associated with ADHD (P＜0.001).3)DSIP was negatively associated with ASQ (P<0.001).The more sleep problems children have,their ASQ were higher and were negatively associated with their academic performance. Conclusion ADHD children have low DSIP levels in blood serum,ADHD is associated with sleep disorder,and can affect the academic performance.