孤独症谱系障碍和发育性语言延迟儿童的听觉处理特征研究
- 梁纯,洪琦,罗小杏,蒋滔滔,高延,姚小芳,卓秀慧,卢光进
作者信息
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Study on central auditory processing characteristics in autism spectrum disorder and developmental language delayed children.
- LIANG Chun,HONG Qi,LUO Xiao-xing,JIANG Tao-tao,GAO Yan,YAO Xiao-fang,ZHUO Xiu-hui,LU Guang-jin.
Author information
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文章历史
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摘要
目的 探讨孤独症谱系障碍和发育性语言延迟儿童的听觉诱发电位特征,为观察两者听觉诱发电位的差异和制定个体语言干预方案提供依据。 方法 对20例孤独症谱系障碍和20例发育性语言延迟儿童进行听觉诱发电位测试,分析各波潜伏期及波间期,并与正常组比较。 结果 孤独症谱系障碍组和发育性语言延迟组分别与正常组比较,III、V波潜伏期和I-III波、I-V波潜伏期均显著延长(P<0.01),而两病例组间差异无统计学意义(P>0.05)。 结论 孤独症谱系障碍和发育性语言延迟儿童可能具有共同的听觉处理缺陷。
Abstract
Objective To investigate and characterize the relationship of brainstem auditory evoked potential changes between the autism spectrum disorder (ASD) and the developmental language delayed (DLD) disorder in young children. Methods Absolute latencies of waves I,III,V,and interpeak latencies(IPLs)of I to III,I to V,and III to V in Brainstem Auditory Evoked Potentials(BAEP)in the ASD group and the DLD group were compared.Either group enrolled 20 children. Results In comparison with normal children,IPLs of I to III and I to V in both ASD group and DLD group were significantly prolonged.However,there were no significant differences between two groups. Conclusion These two disorders might share the same pathological mechanism in the auditory disorder.
关键词
Key words
autism spectrum disorders / developmental language delay / brainstem auditory evoked potentials
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参考文献
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[2] Bishop DV,Snowling MJ.Developmental dyslexia and specific language impaior different?[J].Psychol Bull,2004,130(6):858-886.
[3] Bolton PF,Veltman MW,Weisblatt E,et al.Chromosome 15q11-13 abnormalities and other medical conditions in individuals with autism spectrum disorders[J].Psychiatr Genet,2004,14(3):131-137.
[4] Tomblin JB,Hafeman LL,O'Brien M.Autism and autism risk in siblings of children withspecific language impairment[J].Int J Lang Communication Disorder,2003,38(3):235-250.
[5] Martha R,Herbert,Tal Kenet.Brain abnormalities in language disorders and in autism[J].Pediatr Clin N Am,2007,54:563-583.
[6] Twila T,Paul F,梁卫兰,等.汉语沟通发展量表使用手册[M].北京:北京大学医学出版社,2008:109-149.
[7] Daphne AER,Chava M,Esther S.Evidence for atypical auditory brainstem responses in young children with suspected autism spectrum disorders[J].Developmental Medicine & Child Neurology,2012,54:23-29.
[8] Fernanda CLM,Claudia Inês S,Francisco BAJ.Study of auditory evoked potentials in autism[J].Pró-Fono Revista de Atualização Científica,2010,22(1):31-36.
[9] Rosenhall U,Nordin V,Brantberg K,et al.Autism and auditory brain stem responses[J].Ear Hear,2003,24:206-214. [10] Fujikawa-Brooks S,Isenberg AL,Osann K,et al.The effect of rate stress on the auditory brainstem response in autism:a preliminary report[J].Int J Audiol,2010,49:129-140.
[11] 王陈荣,华清泉,黄治物,等.自闭症患儿的听功能及其传出神经功能评估[J].听力学及言语疾病杂志,2010,18(2):131-132.
[12] Oram CJE,Flagg EJ,Roberts W,et al.Magnetoencephalography identi?es rapid temporal processing deficit in autism and language impairment[J].Neuro Report,2005,16:329-332.
[13] Ponton CW,Eggermont JJ.Electrophysiological measures of human auditory system maturation:relationship with neuroanatomy and behavior[M]//Burkard RF,Don M,Eggermont JJ.Auditory evoked potentials,basic principles and clinical applications.Baltimore:Lippincott,Williams &Wilkins,2007:385-402.
[14] Palmen,Van Engeland H,Hof PR,et al.Neuropathological findings in autism[J].Brain,2004,127:2572-2583.
[15] Courchesne E,Redcay E,Kennedy DP.The autistic brain:birth through adulthood[J].Curr Opin Neurol,2004,17:489-496.
[16] Herbert MR,Ziegler DA,Deutsch CK,et al.Brain asymmetries in autism and developmental language disorder:a nested whole-brain analysis[J].Brain,2005,128:213-226.
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深圳市宝安科技局计划项目(20110618)
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