人乳中脂代谢调控因子的发现,功能和临床意义
- 蒋雪 综述, 李晓南 审校
作者信息
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文章历史
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摘要
研究表明,生命早期的营养和生长可能通过“编程”影响生命后期的代谢。母乳喂养能预防婴儿期乃至成年期肥胖、血糖血脂异常等代谢综合征的发生。这不仅与母乳中的蛋白质、不饱和脂肪酸等含量相关,母乳中新发现的一些代谢调控因子如脂联素、肥胖抑制素、微小核酸、乳脂肪球膜、细胞因子等,亦可能直接或间接调节婴儿的代谢及生长发育。认识这些活性物质的生理作用,有助于促进母乳喂养和成年期疾病的早期预防,也为今后婴儿配方奶粉的改进提供重要的科学依据。
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参考文献
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[2] Lucas A.Programming by early nutrition: an experimental approach[J].J Nutr,1998,128(2s):401-406.
[3] Zhang JV,Ren PG,Avsian-Kretchmer O,et al.Obestatin,a peptide encoded by the ghrelin gene,opposes ghrelin's effects on food intake[J].Science,2005,310(5750):996-999.
[4] Aydin S,Ozkan Y,Erman F,et al.Presence of obestatin in breast milk: relationship among obestatin,ghrelin,and leptin in lactating women[J].Nutrition,2008,24(7-8):689-693.
[5] Nakahara T,Harada T,Yasuhara D,et al.Plasma obestatin concentrations are negatively correlated with body mass index,insulin resistance index,and plasma leptin concentrations in obesity and anorexia nervosa[J].Biol Psychiatry,2008,64(3):252-255.
[6] Egido EM,Hernandez R,Marco J,et al.Effect of obestatin on insulin,glucagon and somatostatin secretion in the perfused rat pancreas[J].Regul Pept,2009,152(1-3):61-66.
[7] Gurriaran-Rodriguez U,Al-Massadi O,Roca-Rivada A,et al.Obestatin as a regulator of adipocyte metabolism and adipogenesis[J].J Cell Mol Med,2011,15(9):1927-1940.
[8] Steppan CM,Bailey ST,Bhat S,et al.The hormone resistin links obesity to diabetes[J].Nature,2001,409(6818):307-312.
[9] Ilcol YO,Hizli ZB,Eroz E.Resistin is present in human breast milk and it correlates with maternal hormonal status and serum level of C-reactive protein[J].Clin Chem Lab Med,2008,46(1):118-124.
[10] Kim KH,Lee K,Moon YS,et al.A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation[J].J Biol Chem,2001,276(14):11252-11256.
[11] Hirai H,Satoh H,Kudoh A,et al.Interaction between resistin and adiponectin in the proliferation of rat vascular smooth muscle cells[J].Mol Cell Endocrinol,2013,366(1):108-116.
[12] Krol J,Loedige I,Filipowicz W.The widespread regulation of microRNA biogenesis,function and decay[J].Nat Rev Genet,2010,11(9):597-610. [13] Izumi H,Kosaka N,Shimizu T,et al.Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions[J].J Dairy Sci,2012,95(9):4831-4841.
[14] Hilton C,Neville MJ,Karpe F.MicroRNAs in adipose tissue: their role in adipogenesis and obesity[J].Int J Obes (Lond),2012,15(5):623-636.
[15] Munch EM,Harris RA,Mohammad M,et al.Transcriptome Profiling of microRNA by Next-Gen Deep Sequencing Reveals Known and Novel miRNA Species in the Lipid Fraction of Human Breast Milk[J].PLoS One,2013,8(2):e50564.
[16] Penttila IA.Milk-derived transforming growth factor-beta and the infant immune response[J].J Pediatr,2010,156(2 S):21-25.
[17] Kainonen E,Rautava S,Isolauri E.Immunological programming by breast milk creates an anti-inflammatory cytokine milieu in breast-fed infants compared to formula-fed infants[J].Br J Nutr,2012:1-9.
[18] Veereman-Wauters G,Staelens S,Rombaut R,et al.Milk fat globule membrane (INPULSE) enriched formula milk decreases febrile episodes and may improve behavioral regulation in young children[J].Nutrition,2012,28(7-8):749-752.
[19] Noh SK,Koo SI.Milk sphingomyelin is more effective than egg sphingomyelin in inhibiting intestinal absorption of cholesterol and fat in rats[J].J Nutr,2004,134(10):2611-2616.
[20] Taverniti V,Guglielmetti S.Health-promoting properties of lactobacillus helveticus[J].Front Microbiol,2012,3:392.
[21] Lonnerdal B.Novel insights into human lactation as a driver of infant formula development[J].Nestle Nutr Workshop Ser Pediatr Program,2010,66:19-29.
[22] Zhang L,Hou D,Chen X,et al.Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA[J].Cell Res,2012,22(1):107-126.
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国家自然科学基金(8127304)
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