儿童人偏肺病毒感染的研究进展
- 高文娟,谢会卿,杨清 综述, 冯惠清 审校
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摘要
呼吸道感染是儿童就医的首要病因,但有些患者的感染病原并不十分清楚,人类偏肺病毒(human metapneumovirus,HMPV)为单分子负链RNA病毒。在全球流行已播散50余年,具有较长的病史,近几年被发现,且流行有明显的季节性。HMPV感染可表现为上、下呼吸道感染、流感样症状、支气管炎、喘息性支气管炎、毛细支气管炎和肺炎等。HMPV感染可以发生在任何年龄组,但儿童(尤其是婴儿)、老年人和免疫功能不全者是重要的易感人群且可与其它病原体形成混合感染。目前有三种HMPV的检测方法 抗原抗体检测、病毒分离和PCR方法检测,实时RT-PCR技术是目前检测HMPV感染的最敏感、最有效的方法。
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参考文献
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[2] 林创兴,陆学东,林广裕,等.粤东地区喘息性疾病患儿中人偏肺病毒的检出与病原学初步研究[J].中华哮喘杂志,2009,31(2):5-7.
[3] Janssen K,Flore K,Piett A,et al.Implementatian of real-time RT-PCR for detection of human metapneumovirus and its comparison with enzyme immunoassay[J].Arch Vieol,2010,155(2):207-215.
[4] Falsey AR,Erdman D,Anderson J,et al.Human metapneumovirus infection in young and elderlyadults[J].J Infect Dis,2003,187(5):785-790.
[5] Sloots TP,Mackay IM,Bialasiewicz S,et al.Human metapneumovirus,Australia,2001-2004[J].Infect Dis,2006,12:1263-1266.
[6] Smuts H,Workman L,Zar HJ.Role of human metapneumovirus,human coronavirus NL63 and human bocavirus in infants and yong children with acute wheezing[J].Med Virol,2008,80(2):906-912.
[7] 朱汝南,钱渊,邓洁,等.北京地区六岁以下儿童急性呼吸道偏肺病毒感染[J].中华儿科杂志,2003,41(3):441-444.
[8] 陈勇.徐州市急性呼吸道感染儿童中人偏肺病毒感染的状况研究[J].预防医学情报杂志,2006,22(5):513-515.
[9] 张琴,杨锡强,赵耀,等.重庆地区0~6岁儿童人类偏肺病毒感染状况调查[J].中国实用儿科杂志,2007,22(2):579-582.
[10] 伍严安,苏跃青,黄毅,等.福州地区儿童急性呼吸道人偏肺病毒感染[J].福建医科大学学报,2007,41(1):433-436.
[11] Peiris JS,Tang WH,Chan KH,et al.Child with respiratory disease associated with metapneumovirus in Hongkong[J].Infect Dis,2003,9:628-633.
[12] Esper F,Marlinelo RA,Boucher D,et al.A 1~6 year experience with human metapneumovirus in children aged 5 years[J].Microbes Infect,2004,189(8):1388-1396.
[13] Mahalingam S,Schworze J,Zaid A,et al.Perspective on the host responseto human metapneumovirus.infection;what can welearn from respiratorysyncytial virus infection?[J].Microbes Infect,2006,8(2):285-293.
[14] 陈俊平.人类偏肺病毒研究概况[J].医学综述,2009,15(14):2150-2152.
[15] 季伟,陈正荣,王宇清,等.呼吸道合胞病毒与人类偏肺病毒急性下呼吸道感染患儿临床表现和肺功能的比较[J].中华儿科杂志,2009,60(1):71-73.
[16] 孙淑华.人类偏肺病毒感染[J].河北医药,2009,31(14):1815-1816.
[17] Zhang SX,Tellier R,Zafar R,et al.Comparison of human metapneumvirus infection with respiratory syncytial virus infection in children.Pediatr[J].Infect Dis,2009,28(11):1022-1024.
[18] Matsuzaki Y,Takashita E,Okamoto M,et al.Evaluation of a new rapid antigen test using immunochromatography for detection of human metapneumovirus in comparison with real-time PCR assay[J].Clin Microbiol,2009,47(9):2981-2984.
[19] Fuenzalide L,Fabrega J,Blanco S,et al.Usefulness of two new methods for diagnosing metapneumovirus infections in children[J].Clin Microbiol Infect,2010,2:11-14.
[20] Amer AO,Swanson MS.Autophagy is an immediate macrophage response to Leionella pneumophila[J].Cell Microbiol,2005,7:765-778.
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