目的 通过比较哮喘与咳嗽变异性哮喘儿童的肺常规通气功能,探讨其临床意义。 方法 选择2010年5-11月就诊于河北省儿童医院呼吸科门诊,确诊为哮喘或咳嗽变异性哮喘的患儿80例,分为:1)哮喘急性发作组(A组)33例,平均年龄(7.96±2.12)岁;2)哮喘缓解组(B组)27例,平均年龄(7.97±1.91)岁;3)咳嗽变异性哮喘组(C组)20例,平均年龄(8.03±2.18)岁;同时随机选择同期正常健康体检儿童30例,作为对照组(D组),平均年龄(8.58±2.11)岁。测定用力肺活量(FVC)、一秒钟用力呼气容积(FEV1)、最大呼气峰流速(PEF)、用力呼气25%流速(FEF25)、用力呼气50%流速(FEF50)、用力呼气75%流速(FEF75)、最大呼气中期流速(MMEF75/25)等7项指标。 结果 A、B、C三组患儿各项肺功能指标均低于D组儿童(B、C组除外PEF、FEF50、FEF75),且A组各项肺功能指标均明显低于B和C组; 但B、C两组患儿差异无统计学意义。 结论 肺常规通气功能检测可以评价哮喘与咳嗽变异性哮喘患儿的气道阻塞程度,对于诊断及病情评估有重要意义。

Objective To explore the clinical significances of pulmonary function test in children with asthma or cough variant asthma (CVA). Methods A total of 80 patients who were diagnosed asthma or CVA at outpatient of Hebei Children's Hospital were selected from May to November in 2010.They had been divided into three groups.Group A for 33 patients with acute asthma,whose average age was (7.96±2.12) years old;group B for 27 patients with asthma remission phase,whose average age was (7.97±1.91) years old;and group C for 20 patients with cough variant asthma,average age was (8.03±2.18) years old.30 children from healthy children were also randomly selected as group D,whose average age was (8.58±2.11) years old.All children were tested by the pulmonary function machine.There were seven pulmonary function indexes,such as forced vital capacity (FVC),forced expiratory volume in one second (FEV1),peak expiratory flow (PEF),forced expiratory flow after 25% (FEF25),forced expiratory low after 50% (FEF50),forced expiratory flow after 75% (FEF75),maximal mid-expiratory flow (MMEF75/25) and so on. Results All the pulmonary function indexes from group A and B and C were lower than those of group D,except PEF,FEF50,FEF75 of group B and C.Each pulmonary function indexes from group A were much lower than those of group B and C,but there was no significant difference between group B and C. Conclusion Pulmonary function test is important to assess the degree of airway obstruction,diagnose and evaluate severity for children with asthma or CVA.