广州地区5岁以下儿童哮喘血清过敏原特点及临床意义
- 程远1,陈德晖2,郑佩燕3
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文章历史
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摘要
目的 了解广州地区5岁以下儿童哮喘常见的血清过敏原情况,探讨血清过敏原检测对5岁以下儿童哮喘诊断的临床意义。方法 选择广州地区5岁以下哮喘儿童为哮喘组,根据不同年龄段分为哮喘I组(＜3岁,146例)、哮喘II组(3~5岁,78例);并选择同期健康体检的正常儿童为正常对照组,根据不同年龄段分为对照I组和对照II组。所有对象通过酶联免疫分析法检测血清TIgE和SIgE。结果 哮喘组血清TIgE和SIgE的阳性率均明显高于对照组(P＜0.01)。广州地区哮喘组中SIgE的吸入过敏原以螨类、屋尘阳性率最高。食物过敏原以牛奶、全蛋为主。哮喘I组食物类过敏原SIgE≥1级、≥2级的阳性率明显高于哮喘II组(P＜0.05);哮喘I组吸入类过敏原SIgE≥1级、≥2级的阳性率明显低于哮喘II组(P＜0.01)。结论 广州地区0~3岁儿童哮喘以食物类过敏原为主,而随着年龄增长3岁后渐过渡以吸入类过敏原为主。血清过敏原检测对早期评估5岁以下儿童哮喘的发生、发展有重要意义。
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参考文献
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[13] De Bilderling G,Mathot M,Aqustsson S,et al.Early skin sensitization to aeroallergens[J].Clin Exp Allergy,2008,38(4):643-648.
[2] Pedersen SE,Hurd SS,Lemanske RE Jr,et al.Global strategy for the diagnosis and management of asthma in children 5 years and younger[EB/OL].Pediatr Pulmonol,2011,46(1):1-17.
[3] 胡亚美,江载芳.诸福棠实用儿科学[M].7版.北京:人民卫生出版社,2002:629-690,1172.
[4] Platts-Mills T,Leung DY,Schatz M.The role of allergens in asthma[J].Am Fam Physician,2007,76(5):675-680.
[5] Pearce N,Pekkanen J,Beasley R.How much asthma is really attributable to atopy[J].Thorax,1999,54:268-272.
[6] 孙宝清,韦妮莉,王红玉,等.呼吸道过敏性疾病患者血清总抗体E检测及意义[J].中国公共卫生,2008,24(1):103-104.
[7] Sherrill D,Stein R,Kurzius-Spencer M,et al.On early sensitization to allergens and development of respiratory symptoms[J].Clin Exp Allergy,1999,29(7):905-911.
[8] HussK,Adkinson NF Jr,Eggleston PA,et al.House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the childhood asthma management program[J].J Allergy Clin Immunol,2001,107(1):48-54.
[9] Hogaboam CM,CarpenterKJ,Schuh JM,et al.Aspergillus and asthma-any link?[J].Med Mycol,2005,43(S):197-202.
[10] Castro-Rodriguez JA,Holberg CJ,Wright AL,et al.A clinical index to define risk of asthma in young children with recurrent wheezing[J].Am J Respir Crit Care Med,2000,162(4Pt1):1403-1406.
[11] Theresa WG,Madison MD.Dentifying and managing the infant and toddler at risk for asthma[J].The Department of Pediatrics,University of Wisconsin-Madison,2010,126:417-422.
[12] 陈德晖,孙宝清,林育能,等.广州地区儿童呼吸道变态反应性疾病常见变应原的流行病学分析[J].国际呼吸病学杂志,2009,29(7):385-388.
[13] De Bilderling G,Mathot M,Aqustsson S,et al.Early skin sensitization to aeroallergens[J].Clin Exp Allergy,2008,38(4):643-648.
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