脑源性神经营养因子与发育行为儿科疾病
- 刘秀梅 综述, 李丽霞 审校
作者信息
+
文章历史
+
摘要
脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)是神经营养素家族的主要成员之一,与神经递质代谢、神经元重塑密切相关,BDNF在注意缺陷多动障碍、抽动障碍、学习障碍、孤独症谱系障碍等多种发育行为儿科疾病中的表达异常,BDNF基因多态性与注意缺陷多动障碍、抽动障碍有关,BDNF参与学习、记忆的过程,能够抗细胞凋亡、促进神经细胞轴突生长,与孤独症发生有关。本文就BDNF与发育行为儿科疾病的相关性做一综述。
关键词
{{custom_sec.title}}
{{custom_sec.title}}
参考文献
[1] Lipsky RH,Marini AM.Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity[J].Ann N Y Acad Sci,2007,1122:130-143.
[2] McAllister TW,Tyler AL,Flashman LA,et al.Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury[J].J Neurotrauma,2012,29(6):1111-1118.
[3] Baumeister AA,Henderson K,Pow JL,et al.The early history of the neuroscience of attention-deficit/hyperactivity disorder[J].J Hist Neurosci,2012,21(3):263-279.
[4] Shim SH,Hwangbo Y,Kwon YJ,et al.Increased levels of plasma brain-derived neurotrophic factor (BDNF) in children with attention deficit-hyperactivity disorder (ADHD)[J].Prog Neuropsychopharmacol Biol Psychiatry,2008,32(8):1824-1828.
[5] Kim H,Heo HI,Kim DH,et al.Treadmill exercise and methylphenidate ameliorate symptoms of attention deficit/hyperactivity disorder through enhancing dopamine synthesis and brain-derived neurotrophic factor expression in spontaneous hypertensive rats[J].Neurosci Lett,2011,504(1):35-39.
[6] Bergman O,Westberg L,Lichtenstein P,et al.Study on the possible association of brain-derived neurotrophic factor polymorphism with the developmental course of symptoms of attention deficit and hyperactivity[J].Int J Neuropsychopharmacol,2011,14(10):1367-1376.
[7] Ribasés M,Hervás A,Ramos-Quiroga JA,et al.Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder[J].Biol Psychiatry,2008,63:935-945.
[8] Xu X,Mill J,Zhou K,et al.Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples[J].Am J Med Genet B Neuropsychiatr Genet,2007,144B (1):83-86.
[9] Cho SC,Kim HW,Kim BN,et al.Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder[J].Psychiatry Investig,2010,7(4):285-290. [10] Janik P,Kalbarczyk A,Gutowicz M,et al.The analysis of selected neurotransmitter concentrations in serum of patients with Tourette syndrome[J].Neurol Neurochir Pol,2010,44(3):251-259.
[11] Gadow KD,Roohi J,DeVincent CJ,et al.Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety,ADHD and tics in children with autism spectrum disorder[J].J Autism Dev Disord,2009,39(11):1542-1551.
[12] Klaffke S,Knig IR,Poustka F,et al.Brain-derived neurotrophic factor:a genetic risk factor for obsessive-compulsive disorder and Tourette syndrome?[J].Mov Disord,2006,21(6):881-883.
[13] Erickson KI,Miller DL,Roecklein KA.The aging hippocampus:interactions between exercise,depression,and BDNF[J].Neuroscientist,2012,18(1):82-97.
[14] Grassi-Oliveira R,Stein LM,Lopes RP,et al.Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression-a preliminary report[J].Biol Psychiatry,2008,64(4):281-285.
[15] Gorski JA,Balogh SA,Wehner JM,et al.Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice[J].Neuroscience,2003,121(2):341-354.
[16] Betancur C.Etiological heterogeneity in autism spectrum disorders:more than 100 genetic and genomic disorders and still counting[J].Brain Res,2011,1380:42-77.
[17] Raznahan A,Toro R,Proitsi P,et al.A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorder[J].J Neurodev Disord,2009,1(3):215-223.
[18] Correia CT,Coutinho AM,Sequeira AF,et al.Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism[J].Genes Brain Behav,2010,9(7):841-848.
[19] Katoh-Semba R,Wakako R,Komori T,et al.Age-related changes in BDNF protein levels in human serum:differences between autism cases and normal controls[J].Int J Dev Neurosci,2007,25(6):367-372.
[20] Croen LA,Goines P,Braunschweig D,et al.Brain-derived neurotrophic factor and autism:maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) Study[J].Autism Res,2008,1(2):130-137.
[21] Sheikh AM,Malik M,Wen G,et al.BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects[J].J Neurosci Res,2010,88(12):2641-2647.
[2] McAllister TW,Tyler AL,Flashman LA,et al.Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury[J].J Neurotrauma,2012,29(6):1111-1118.
[3] Baumeister AA,Henderson K,Pow JL,et al.The early history of the neuroscience of attention-deficit/hyperactivity disorder[J].J Hist Neurosci,2012,21(3):263-279.
[4] Shim SH,Hwangbo Y,Kwon YJ,et al.Increased levels of plasma brain-derived neurotrophic factor (BDNF) in children with attention deficit-hyperactivity disorder (ADHD)[J].Prog Neuropsychopharmacol Biol Psychiatry,2008,32(8):1824-1828.
[5] Kim H,Heo HI,Kim DH,et al.Treadmill exercise and methylphenidate ameliorate symptoms of attention deficit/hyperactivity disorder through enhancing dopamine synthesis and brain-derived neurotrophic factor expression in spontaneous hypertensive rats[J].Neurosci Lett,2011,504(1):35-39.
[6] Bergman O,Westberg L,Lichtenstein P,et al.Study on the possible association of brain-derived neurotrophic factor polymorphism with the developmental course of symptoms of attention deficit and hyperactivity[J].Int J Neuropsychopharmacol,2011,14(10):1367-1376.
[7] Ribasés M,Hervás A,Ramos-Quiroga JA,et al.Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder[J].Biol Psychiatry,2008,63:935-945.
[8] Xu X,Mill J,Zhou K,et al.Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples[J].Am J Med Genet B Neuropsychiatr Genet,2007,144B (1):83-86.
[9] Cho SC,Kim HW,Kim BN,et al.Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder[J].Psychiatry Investig,2010,7(4):285-290. [10] Janik P,Kalbarczyk A,Gutowicz M,et al.The analysis of selected neurotransmitter concentrations in serum of patients with Tourette syndrome[J].Neurol Neurochir Pol,2010,44(3):251-259.
[11] Gadow KD,Roohi J,DeVincent CJ,et al.Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety,ADHD and tics in children with autism spectrum disorder[J].J Autism Dev Disord,2009,39(11):1542-1551.
[12] Klaffke S,Knig IR,Poustka F,et al.Brain-derived neurotrophic factor:a genetic risk factor for obsessive-compulsive disorder and Tourette syndrome?[J].Mov Disord,2006,21(6):881-883.
[13] Erickson KI,Miller DL,Roecklein KA.The aging hippocampus:interactions between exercise,depression,and BDNF[J].Neuroscientist,2012,18(1):82-97.
[14] Grassi-Oliveira R,Stein LM,Lopes RP,et al.Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression-a preliminary report[J].Biol Psychiatry,2008,64(4):281-285.
[15] Gorski JA,Balogh SA,Wehner JM,et al.Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice[J].Neuroscience,2003,121(2):341-354.
[16] Betancur C.Etiological heterogeneity in autism spectrum disorders:more than 100 genetic and genomic disorders and still counting[J].Brain Res,2011,1380:42-77.
[17] Raznahan A,Toro R,Proitsi P,et al.A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorder[J].J Neurodev Disord,2009,1(3):215-223.
[18] Correia CT,Coutinho AM,Sequeira AF,et al.Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism[J].Genes Brain Behav,2010,9(7):841-848.
[19] Katoh-Semba R,Wakako R,Komori T,et al.Age-related changes in BDNF protein levels in human serum:differences between autism cases and normal controls[J].Int J Dev Neurosci,2007,25(6):367-372.
[20] Croen LA,Goines P,Braunschweig D,et al.Brain-derived neurotrophic factor and autism:maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) Study[J].Autism Res,2008,1(2):130-137.
[21] Sheikh AM,Malik M,Wen G,et al.BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects[J].J Neurosci Res,2010,88(12):2641-2647.
基金
国家自然科学基金资助项目(81101017);山东省优秀中青年科学家科研奖励基金(BS2010F030);烟台市科学技术发展计划项目(2010148-24)
-
总访问量
今日访问
在线人数
扫一扫，关注本刊微信公众号
版权所有 © 《中国儿童保健杂志》编辑部
技术支持：北京玛格泰克科技发展有限公司
技术支持：北京玛格泰克科技发展有限公司
/
| 〈 |
|
〉 |