【目的】 初步探讨儿童后期哮喘患病与早期羅患呼吸道感染性疾病之间的关系。 【方法】 共317例哮喘儿童纳入研究,317例非喘息性疾病患儿作为对照。采用向家长书面问卷调查方法询问各组婴儿围产期因素、家族史及既往呼吸道感染性疾病等资料进行综合调查。采用后退法进行哮喘患病危险因素的多因素配比条件Logistic回归分析。 【结果】 在校正了其他与儿童哮喘发生发展密切相关的因素后,既往上/下呼吸道感染次数以及下呼吸道初发年龄与儿童期哮喘的发病存在密切相关;上呼吸道感染和下呼吸道感染的发作次数以及下呼吸道感染的初次发作年龄均与哮喘中度、重度发作关系密切。上呼吸道感染初次发作年龄与儿童哮喘发作以及病情程度均无显著关系。 【结论】 本地区儿童早期呼吸道感染与儿童四岁左右哮喘的发生发展以及发作程度密切相关。

【Objective】 To explore the association of early respiratory infection and children's current asthma. 【Methods】 A total of 317 children with average aged about 4 years were recruited into the study group and 317 healthy children without asthma were categorized into the control group.The parents of these children were responded to a questionnaire covering demographic factors,lifestyle,home environment,and health history,including a detailed history of respiratory conditions.Back multi-factor matched conditional logistic regression analysis was used to analyze the risk factors of children's asthma about four years old. 【Results】 After adjustment for the other covariate factors,the data indicated the significant association of current asthma and the degree with the numbers of upper/low respiratory infection and the age of onset of low respiratory infection in the past year.No significant correlation was found between the ages of onset of upper respiratory infection with current asthma and the degree. 【Conclusion】 There are associations of early respiratory infection with children's current asthma in locality.