【目的】 调查单纯性肥胖儿童生长变化及血清胰岛素样生长因-1(IGF-1)/胰岛素样生长因子结合蛋白3(IGFBP-3)浓度。 【方法】 根据广州两所小学从7岁开始建立的身高/体重纵向体检资料,然后依据体质指数分类标准筛选7岁以来一直处于正常体重和肥胖的11岁儿童,同时以父母身高中值为配对因素,选取一直肥胖的儿童31人(男20,女11)和一直体重正常的儿童42人(男20,女22)分析身高纵向变化,并测试空腹血清IGF-1/IGFBP3浓度。 【结果】 肥胖组男童身高高于同龄时正常体重儿童,且11岁时IGF-1/IGFBP3浓度皆高于正常体重儿童(P<0.05);女童肥胖组与正常组身高差异则无统计学意义,11岁时IGF-1/IGFBP3浓度也无显著变化。 【结论】 单纯性肥胖并不影响青春期前(或青春期)儿童的生长或反使生长加速,相应的血清IGF-1/IGFBP3浓度无改变或增加。
Abstract
【Objective】 To investigate the longitudinal growth and serum IGF-1/IGFBP3 levels in simple obese children. 【Methods】 Height/weight data were collected in a health examination cohort from ages 7~11 years old in two primary schools in Guangzhou.According to body mass index (BMI) classification references for normal weight and obesity,31 (20 boys and 11 girls) sustained simple obese (SSO) children and 42 (20 boys and 22 girls) gender and mid-parental height-matched sustained normal weight (SNW) children were screened to analyze the longitudinal changes of height from 7 to 11 years old and to determine the fast serum IGF-1/IGFBP3 levels at 11 years old. 【Results】 The height was taller in SSO boys than in matched SNW boys at each corresponding age,and basal IGF-1/IGFBP3 levels were also higher in SSO boys than in matched SNW boys at 11 years old (P<0.05).There was no significant difference in height between SSO and matched SNW girls,nor did in basal IGF-1/IGFBP3 between SSO girls and matched SNW girls at 11 years old. 【Conclusion】 Simple obese prepubertal or pubertal children have normal linear growth or accelerated linear growth with normal or increased basal serum IGF-1/IGFBP3 levels correspondingly.
关键词
肥胖 /
生长 /
胰岛素样生长因-1
Key words
obesity /
growth /
IGF-1
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基金
广东省自然科学基金项目(S2011010001160)
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