凝血酶与气道重塑的研究进展

秦明明,朱薇薇,李峰

中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (6) : 527-529.

PDF(466 KB)
PDF(466 KB)
中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (6) : 527-529.
综述与讲座

凝血酶与气道重塑的研究进展

  • 秦明明,朱薇薇,李峰
作者信息 +
文章历史 +

摘要

气道重塑是支气管哮喘的重要特征之一,大量研究表明,生长因子、细胞因子、炎性介质和酶等多种因素参与气道重塑。目前,部分细胞因子对气道重塑的影响机制已相对明确,而凝血酶对气道重塑的影响研究目前很少,本文就近年来凝血酶与气道重塑的研究进展阐述如下。

关键词

凝血酶 / 气道重塑 / 支气管哮喘

引用本文

导出引用
秦明明,朱薇薇,李峰. 凝血酶与气道重塑的研究进展[J]. 中国儿童保健杂志. 2012, 20(6): 527-529
中图分类号: R725.6   

参考文献

[1] Mauad T,Elisabeth HB,Peter JS.Asthma therapy and airway remodeling[J].J Allergy Clin Immunol,2007,120:997-1009.
[2] Greenlee KJ,Werb Z,Kheradmand F.Matrix metalloproteinases in lung:multiple,multifarious,and multifaceted[J].Physiol Rev,2007,87(1):69-98.
[3] 石建霞,顾健.凝血酶与肿瘤的血管新生[J].中国实验血液学杂志,2006,14(1):197-200.
[4] Hua Y,Keep RF,Gu Y,et al.Thrombin and Brain Recovery After Intracerebral Hemorrhage[J].Stroke,2009,40(3S):88-89.
[5] 朱蕴兰,李爽,于丰源,等.凝血酶受体在多发性骨髓瘤细胞×G-1增殖和抗凋亡作用中的机制[J].苏州大学学报:医学版,2010,30(1):15-18.
[6] Liang KC,Lee CW,Lin WN,et al.Interleukin-1beta induces MMP-9 expression via P42/P44 MAPK,p38 MAPK,JNK,and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells[J].J Cell Physiol,2007,211:759-770.
[7] Saetta M,Turato G.Airway pathology in asthma[J].Eur Respir J Suppl,2001,34(S):18-23.
[8] Tagaya E,Tamaoki J.Mechanisms of Airway Remodeling in Asthma[J].Allergol Int,2007,56:331-340.
[9] Radjabi AR,Sawada K,Jagadeeswaran S,et al.Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta-integrin on the cell surface[J].J Biol Chem,2008,283(5):2822-2834.
[10] Gluck N,Schwob O,Krimsky M,et al.Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation[J].Am J Physiol Cell Physiol,2008,294:1597-1603.
[11] Halayko AJ,Kartha S,Stelmack GL,et al.Phophatidylinosi-tol-3 kinase/mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation[J].Am J Respir Cell Mol Biol,2004,31:266-275.
[12] Vera PK,Elena AG.Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration[J].The FASEB Journal,2005,19(3):428-430.
[13] 李斌,李艳会,徐玲娟,等.VEGF映射 ROP新生血管的初步研究[J].国际眼科杂志,2008,8(11):2187-2188.
[14] Tsopanoglou NE,Maragoudakis E.Inhibition of angiogenesis by small-molecule antagonists of protease-activated receptor-1[J].Semin Thromb Hemost,2007,33:680-687.
[15] Huang YQ,Li JJ,Hu L,et al.Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts,DU 145 prostate cells and CHRF megakaryocytes[J].Thromb Haemost,2001,86:1094-1098.
[16] Zhang H,Liu ZL.Expression of FLK-1 in laser-induced choroidal neo-vascularization in mouse[J].Int J Ophthamlol,2007,7(3):642-644.
[17] Zheng L,Martins-Green M.Molecular mechanisms of thrombin-induced interleukin-8(IL-8/CXCL8)expression in TH P-1-derived and primary human macrophages[J].J Leukoc Biol,2007,82:619-629.

PDF(466 KB)

Accesses

Citation

Detail

段落导航
相关文章

/