miRNA与脂肪细胞分化、肥胖

季晨博 综述, 郭锡熔 审校

中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (5) : 419-423.

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中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (5) : 419-423.
综述与讲座

miRNA与脂肪细胞分化、肥胖

  • 季晨博1,2 综述, 郭锡熔1,2 审校
作者信息 +
文章历史 +

摘要

肥胖已经成为全球面临的一个严重公共健康问题。肥胖是机体能量失衡导致脂肪过度积聚为重要特征的一种代谢异常,主要表现为脂肪细胞数量异常增加和体积异常增大,因此深入理解脂肪细胞分化机制对肥胖防治具有重要意义。microRNA(miRNA)是近年来在真核生物体内发现的、一类长度约22nt的内源性非编码单链小RNA,通过与靶标mRNA不完全互补配对,发挥降解靶mRNA或抑制靶mRNA翻译的作用。miRNA几乎参与所有生命活动的调节和大多数疾病的发病过程,包括脂肪细胞分化、肥胖发生发展。本文主要综述miRNA在脂肪细胞分化、肥胖研究领域取得的成果,并分析该领域的现状、不足及前景。

关键词

miRNA / 脂肪细胞 / 分化 / 肥胖

引用本文

导出引用
季晨博 综述, 郭锡熔 审校. miRNA与脂肪细胞分化、肥胖[J]. 中国儿童保健杂志. 2012, 20(5): 419-423
中图分类号: R725   

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基金

江苏省医学创新团队项目(LJ201108);江苏省自然科学基金(BK2011107);南京市科技发展计划(201104013)

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