【目的】 研究妊娠期高血压疾病(hypertension disorder complicating pregnancy,HDCP)对围产儿结局的影响及胎儿脐动脉血流变化与围产儿不良结局的关系。 【方法】 对57例妊娠期高血压疾病孕产妇和59例正常妊娠孕产妇的妊娠结局进行观察,测量胎儿脐动脉血流指标并观察两组围产儿结局。 【结果】 HDCP组围产儿的不良结局在新生儿窒息、早产和低出生体重方面的发生率均高于正常组(P<0.05);两组在脐动脉血流搏动指数(PI)、阻力指数(RI)、收缩压最大血流速度与舒张末期最大血流速度比值(S/D)等三个指标上存在的差异有统计学意义(P<0.05)。胎儿脐动脉血流指标与围产儿出生结局呈负相关关系。 【结论】 HDCP患者更容易发生围产儿不良结局,胎儿脐动脉血流指标更易出现异常。脐动脉血流指标RI和S/D比值可以用来预测围产儿不良结局的发生。
Abstract
【Objective】 To study the impact of hypertension disorder complicating pregnancy(HDCP) on pregnancy outcome and to investigate the relationship between index of umbilical artery blood flow and pregnancy adverse outcomes. 【Method】 A prospective survey of 57 HDCP patients and 59 normal pregnant women were selected,the perinatal outcomes were observed,and the index of fetal growth and umbilical artery blood flow were recorded. 【Results】 In the incidence rates of neonate asphyxia,premature labor,fetal low birth weight,and the index of umbilical artery blood flow,HDCP group were significantly higher than those of normal group(P<0.05).Between umbilical artery blood flow and pregnancy outcomes,there was a significant negative correlation. 【Conclusions】 Adverse pregnancy outcomes and abnormal umbilical artery blood flow indices are more likely to appear in HDCP mothers. Indices of uterine artery flow can predict the occur of adverse pregnancy outcomes.
关键词
妊娠期高血压 /
围产儿结局 /
脐动脉血流
Key words
hypertension disorder complicating pregnancy /
perinatal outcome /
umbilical artery blood flow
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基金
国家自然科学基金(30771818,81172682)
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