【目的】 分析遗传和环境因素对学龄前双生子儿童围度发育的影响及其性别和年龄因素的作用。 【方法】 对3~6岁101对双生子(同卵双生子42对、同性别异卵双生子30对,异性别异卵双生子29对)的头围、胸围、腰围、臀围、上臂围及小腿围进行测量;对测量结果进行结构方程模型拟合,并估算各指标遗传度。 【结果】 最佳模型除头围为AES外,其他各指标均为ACES模型,遗传、环境、年龄因素对各指标均有不同程度影响。校正年龄后,各指标遗传度为:头围(男0.83,女0.75)、胸围(男0.56,女0.43)、腰围(男0.77,女0.72)、臀围(男0.49,女0.63)、上臂围(男0.58,女0.36)、小腿围(男0.82,女0.76)。 【结论】 学龄前儿童头围、腰围、小腿围主要受遗传因素影响,胸围、臀围、上臂围受环境因素影响相对较大。
Abstract
【Objective】 To assess the genetic and environmental influences on body circumference of preschool-age children,and the effect of sex and age. 【Methods】 A total of 101 twin pairs aged 3~6 years old were measured,including 42 monozygotic (MZ),30 like-sex and 29 opposite-sex dizygotic (DZ).The circumference items included head circumference,chest circumference,waist circumference,hip circumference,arm circumference and calf circumference.The structural equation modeling was used to evaluate the heritability of each circumference item. 【Results】 Except head circumference's fitting model was AES,others were ACES,which indicated that the circumference items were influenced by genetic,environmental factors and age effects.After adjusting age,the heritabilities of head circumference,chest circumference,waist circumference,hip circumference,arm circumference and calf circumference were 0.83,0.56,0.77,0.49,0.58,0.82 in boys,and 0.75,0.43,0.72,0.63,0.36,0.76 in girls respectively. 【Conclusion】 The circumference of head,waist and calf of preschool-age children are mainly influenced by genetic factors,the circumferences of chest,hip and arm are mainly influenced on environmental ones.
关键词
围度 /
学龄前儿童 /
双生子 /
遗传度
Key words
circumference /
preschool-age children /
twins /
heredity
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基金
国家自然科学基金(30960167);国家自然科学基金(30371223);内蒙古自然科学基金(200508010507)
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