铁缺乏对啮齿类动物中枢神经系统的影响

邱晓露 综述, 李国林、邹时朴 审校

中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (11) : 1005-1007.

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中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (11) : 1005-1007.
综述与讲座

铁缺乏对啮齿类动物中枢神经系统的影响

  • 邱晓露 综述, 李国林、邹时朴 审校
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摘要

铁缺乏(iron deficiency,ID)是最常见的营养素缺乏症和全球性健康问题,6~24月婴幼儿是儿童铁缺乏的高危人群。啮齿类动物铁缺乏的研究也模仿人类,研究胎儿期到断奶期的幼鼠,此时是啮齿类动物神经系统发育的敏感期。在啮齿类动物研究中发现单纯铁缺乏不但可以导致脑内铁、单胺类化合物及其转运体、受体受到不同程度的影响,还影响中枢神经系统髓鞘化形成,导致幼鼠即使经过治疗后仍然表现为行为、学习、记忆等受损。本文就啮齿类动物铁缺乏对中枢神经系统的影响进行综述。

关键词

铁缺乏 / 中枢神经系统 / 啮齿类动物

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邱晓露 综述, 李国林、邹时朴 审校. 铁缺乏对啮齿类动物中枢神经系统的影响[J]. 中国儿童保健杂志. 2012, 20(11): 1005-1007
中图分类号: R722   

参考文献

[1] Beard JL,Felt B,Schallert T,et al.Moderate iron deficiency in infancy:Biology and behavior in young rats[J].Behavioural Brain Research,2006,170(2):224-232.
[2] Tran PV,Fretham SJ,Wobken J,et al.Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampus[J].Am J Physiol Endocrinol Metab,2012,302(3):316-324.
[3] Kawano F,Oke Y,Nomura S,et al,Responses of HSC70 expression in diencephalon to iron deficiency anemia in rats[J].J Physiol Sci,2011,61(6):445-456.
[4] Phu VT,Fretham SJ,Erik SC,et al.Long-term reduction of hippocampal brain-derived neurotrophic factor activity after fetal-neonatal iron deficiency in adult rats[J].Pediatric Research,2009,65(5):493-498.
[5] Hahn P,Song Y,Ying GS,et al.Age-dependent and gender-specific changes in mouse tissue iron by strain[J].Experimental Gerontology,2009,44:594-600.
[6] Erica LU,Wiesinger JA,Hao L,et al.Dopamine D2 receptor expression is altered by changes in cellular iron levels in PC12 cells and rat brain tissue[J].J Nutr,2008,138:2487-2494.
[7] Seema G,Earley CJ,Simonetta C,et al.Mughal diminished iron concentrations increase adenosine A2A receptor levels in mouse striatum and cultured human neuroblastoma cells[J].Experimental Neurology,2009,215:236-242.
[8] Wu LL,Zhang L,Shao J,et al.Effect of perinatal iron deficiency on myelination and associated behaviors in rat pups[J].Behavioural Brain Research,2008,188(2):263-270.
[9] Brunette KE,Tran PV,Wobken JD,et al.Gestational and neonatal iron deficiency alters apical dendrite structure of CA1 pyramidal neurons in adult rat hippocampus[J].Dev Neurosci,2010,32(3):238-248.
[10] DeMaman AS,Homem JM,Lachat JJ,et al.Early iron deficiency produces persistent damage to visual tracts in Wistar rats[J].Nutr Neurosci,2008,11(6):283-289.
[11] Lee DL,Strathmann FG,Gelein R,et al.Irondeficiency disrupts axon maturation of the developing auditory nerve[J].J Neurosci,2012,32(14):5010-5015.
[12] Takeshi I,Yamate J,Robin JM,et al.Abnormal iron accumulation is involved in the pathogenesis of the demyelinating dmy rat but not in the hypomyelinating mv rat[J].Brain Research,2010,1349:105-114.
[13] Rosato-Siri MV,Badaracco ME,Ortiz EH,et al.Oligodendrogenesis in iron-deficient rats:effect of apotransferrin[J].J Neurosci Res,2010,88(8):1695-1707.
[14] Barbara TF,Beard JL,Timothy S,et al.Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats[J].Behavioural Brain Research,2006,171:261-270.
[15] Gewirtz JC,Hamilton KL,Babu MA,et al.Effects of gestational iron deficiency on fear conditioning in juvenile and adult rats[J].Brain Research,2008,1237:195-203.
[16] Carlson ES,Fretham SJ,Unger E,et al,Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems[J].Journal of Neurodevelopmental Disorders,2010,2 (3):133-143.
[17] Adam TS,Alvarez GC,William MG,et al.Early iron deficiency enhances stimulus-response learning of adult rats in the context of competing spatial information[J].Developmental Cognitive Neuroscience,2012,2:174-180.
[18] Schmidt AT,Ladwig EK,Wobken JD,et al.Delayed alternation performance in rats following recovery from early iron deficiency[J].Physiology and Behavior,2010,101:503-508.
[19] McEchron MD,Goletiani CJ,Alexander DN,et al.Perinatal nutritional iron deficiency impairs noradrenergic-mediates synaptic efficacy in the CA1 area of rat hippocampus[J].J Nutr,2010,140:642-647.
[20] Mohamed WM,Unger EL,Kambhampati SK,et al.Methylphenidate improves cognitive deficits produced by infantile iron deficiency in rats[J].Behavioural Brain Research,2011,216(1):146-152.

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