促红细胞生成素在新生儿缺氧缺血性脑病中的研究进展
- 王钰 综述, 尹晓娟 审校
作者信息
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文章历史
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摘要
缺氧缺血性脑病(hypoxic-ischemic encephalopathy, HIE)是因为围生期窒息缺氧所引起的缺氧性缺血脑损害,是新生儿时期危害性最大的疾病之一,重度HIE患儿可造成死亡,部分存活儿可留有癫痫、脑瘫、学习困难等神经系统后遗症,目前尚缺乏有效的治疗方法。促红细胞生成素(erythropoietin, Epo)对HIE可能具有潜在的脑保护作用,本文就Epo可能的脑保护作用、脑保护的机制以及Epo应用中的副作用进行综述,以其提高人们对Epo在HIE脑保护作用中的认识。
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参考文献
[1] Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy[J]. N Engl J Med,2009,361(14):1349-1358.
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[6] Bierer R,Peceny MC,Hartenberger CH, et al.Erythropoietin concentrations and neurodevelopmental outcome in preterm infants[J]. Pediatrics,2006,118(3):e635-e640.
[7] Brown MS, Eichorst D, Lala-Black B, et al. Higher cumulative doses of erythropoietin and developmental outcomes in preterm infants[J]. Pediatrics,2009,124(4):e681-687.
[8] Zhu C, Kang W, Xu F, et al. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy[J]. Pediatrics,2009,124(2):e218-226.
[9] Strunk T, Hartel C, Temming P, et al. Erythropoietin inhibits cytokine production of neonatal and adult leukocytes[J]. Acta Paediatr,2008,97(1):16-20.
[10] Martini WZ. The effects of hypothermia on fibrinogen metabolism and coagulation function in swine[J]. Metabolism,2007,56(1):214-221.
[11] Lin S, Fan LW, Rhodes PG, et al. Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats[J]. Exp Neurol,2009,217(2):361-370.
[12] Byts N, Samoylenko A, Fasshauer T, et al. Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin[J]. Cell Death Differ,2008,15(4):783-792.
[13] Shang Y, Wu Y, Yao S, et al. Protective effect of erythropoietin against ketamine-induced apoptosis in cultured rat cortical neurons: involvement of PI3K/Akt and GSK-3 beta pathway[J]. Apoptosis,2007,12(12):2187-2195.
[14] Sanchez PE, Navarro FP, Fares RP, et al. Erythropoietin receptor expression is concordant with erythropoietin but not with common beta chain expression in the rat brain throughout the life span[J]. J Comp Neurol,2009,514(4):403-414.
[15] Schelshorn DW, Schneider A, Kuschinsky W, et al. Expression of hemoglobin in in rodent neurons[J]. J Cereb Blood Flow Metab,2009,29(3):585-595.
[16] Chen J, Connor KM, Aderman CM, et al. Erythropoietin deficiency decreases vascular stability in mice[J]. J Clin Invest,2008,118(2):526-533.
[2] McPherson RJ, Juul SE. Recent trends in erythropoietin-mediated neuroprotection[J]. Int J Dev Neurosci,2008,26(1):103-111.
[3] McPherson RJ, Demers EJ, Juul SE. Safety of high-dose recombinant erythropoietin in a neonatal rat model[J]. Neonatology,2007,91(1):36-43.
[4] Fauchere JC, Dame C, Vonthein R, et al. An approach to using recombinant erythropoietin for neuroprotection in very preterm infants[J]. Pediatrics,2008,122(2):375-382.
[5] Juul SE, McPherson RJ, Bauer LA, et al. A phase I/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safet[J]. Pediatrics,2008,122(2):383-391.
[6] Bierer R,Peceny MC,Hartenberger CH, et al.Erythropoietin concentrations and neurodevelopmental outcome in preterm infants[J]. Pediatrics,2006,118(3):e635-e640.
[7] Brown MS, Eichorst D, Lala-Black B, et al. Higher cumulative doses of erythropoietin and developmental outcomes in preterm infants[J]. Pediatrics,2009,124(4):e681-687.
[8] Zhu C, Kang W, Xu F, et al. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy[J]. Pediatrics,2009,124(2):e218-226.
[9] Strunk T, Hartel C, Temming P, et al. Erythropoietin inhibits cytokine production of neonatal and adult leukocytes[J]. Acta Paediatr,2008,97(1):16-20.
[10] Martini WZ. The effects of hypothermia on fibrinogen metabolism and coagulation function in swine[J]. Metabolism,2007,56(1):214-221.
[11] Lin S, Fan LW, Rhodes PG, et al. Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats[J]. Exp Neurol,2009,217(2):361-370.
[12] Byts N, Samoylenko A, Fasshauer T, et al. Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin[J]. Cell Death Differ,2008,15(4):783-792.
[13] Shang Y, Wu Y, Yao S, et al. Protective effect of erythropoietin against ketamine-induced apoptosis in cultured rat cortical neurons: involvement of PI3K/Akt and GSK-3 beta pathway[J]. Apoptosis,2007,12(12):2187-2195.
[14] Sanchez PE, Navarro FP, Fares RP, et al. Erythropoietin receptor expression is concordant with erythropoietin but not with common beta chain expression in the rat brain throughout the life span[J]. J Comp Neurol,2009,514(4):403-414.
[15] Schelshorn DW, Schneider A, Kuschinsky W, et al. Expression of hemoglobin in in rodent neurons[J]. J Cereb Blood Flow Metab,2009,29(3):585-595.
[16] Chen J, Connor KM, Aderman CM, et al. Erythropoietin deficiency decreases vascular stability in mice[J]. J Clin Invest,2008,118(2):526-533.
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