【目的】 探索经新生儿疾病筛查程序诊治的先天性甲状腺功能减低症(congenital hypothyroidism, CH)智力特点,分析其与疾病本身及治疗因素的关系,为正确评估预后、探索更完善的治疗方案提供依据。 【方法】 以7~18岁CH56例为研究对象,用韦氏智力诊断量表(C-WISC)进行智力测查,结果与正常人群标准值比较,应用SPSS13.0进行统计学分析。 【结果】 CH智商与正常人群标准值(100±15)比较差异无统计学意义(P＞0.05);其与诊断时T₄水平、甲状腺组织发育情况及治疗初期甲状腺功能恢复情况呈显著或非常显著正相关(r=0.336~0.660,P=0.024~0.000),与治疗年龄呈负相关(r=0.295,P=0.049)。 【结论】 CH智力分布特点与正常人群一致;病情程度及治疗初期甲状腺功能恢复情况是影响智力发育的重要因素。

【Objective】 Through exploring the intellectual characteristics of patients with congenital hypothyroidism(CH) diagnosed by neonatal screening program and analyzing the relations between intelligence and the disease itself or therapy factors, and to provide a basis for more exactly evaluating the outcomes and exploring more perfect therapeutic schedule. 【Methods】 The subjects were the CH patients aged from 7 to 18 years old. Intelligence tests were completed in all patients using China Wechsler intelligence scale for children(C-WISC). The patients' intelligence quotients were compared with those of normal population. Statistic analyzing was conducted using the SPSS 13.0 statistic software for Windows. 【Results】 The difference between intelligence quotients(IQ) of CH patients and standard value of normal population(100±15) was not significant(P>0.05). The IQ of CH patients had significant or very significant positive correlation with T4 concentrations at the time of CH were diagnosed, the severity of thyroid gland hypoplasia, level of restoring thyroid function at the beginning of therapy(r=0.336~0.660, P=0.024~0.000) and a negative correlation with the age of initial treatment(r=0.295,P=0.049). 【Conclusions】 The intelligence distribution characteristic of CH patients is consistent with the normal population. The important factors affecting the intellectual development in CH patients were severity of CH and level of restoring thyroid function at the beginning of therapy.