【目的】 比较矮小儿童精氨酸与左旋多巴单日复合与两日序贯两种方式激发生长激素(growth hormone, GH)分泌的试验效果。 【方法】 将77例矮小症儿童随机分为两组,单日复合组(复合组)39例,精氨酸、左旋多巴清晨一次同时给予,复合进行GH激发;两日序贯组(序贯组)38例,精氨酸、左旋多巴分两天,序贯进行GH激发,以任一次测得的最高值为峰值,GH峰值>10 ng/mL为激发试验阳性;GH峰值<10 ng/mL,为激发试验阴性。比较两种方法激发GH分泌的峰值强度及阳性率。 【结果】 复合组GH峰值(15.55±7.50) ng/mL,阳性率82.0%(32/39);序贯组GH峰值(13.80±9.23) ng/mL,阳性率60.5%(23/38),阳性率复合组明显高于序贯组,差异有统计学意义(P<0.05),两组间峰值比较差异无统计学意义(P>0.05)。 【结论】 精氨酸左旋多巴单日复合GH激发试验有较高阳性率,能更好的激发GH分泌。

【Objective】 To compare the effects of two growth hormone(GH) provocative tests(arginine and levodopa combined or sequential ways) among children with short stature. 【Methods】 77 children with short stature were divided into 2 groups randomly. The combined group(39 cases) was given with arginine and levodopa at the same time to stimulate GH secretion, while the sequential group(38 cases) was given with arginine and levodopa separately in two days. The peak value of GH and the positive incidence of the two stimulation tests were compared. Peak value <10 ng/mL was defined as negative test and peak value >10 ng/mL was defined as positive test. 【Results】 The GH peak value in combined group and sequential group were(15.55±7.50) ng/mL and(13.80±9.23) ng/mL respectively. The incidence of positive test in combined group(82.0%) was significantly higher than sequential group(60.5%). 【Conclusion】 The GH provocative test performed in combined way has a higher positive incidence than in sequential way, and is more reliable in diagnosing GH deficiency.