2001-2010年北京市5岁以下儿童先天异常死亡状况分析
- 朱雪娜,闫淑娟,李东阳
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Mortality from congenital malformation in children under 5 years old in Beijing, 2001-2010
- ZHU Xue-na, YAN Shu-juan, LI Dong-yang
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文章历史
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摘要
【目的】 了解2001-2010年北京市5岁以下儿童先天异常死亡的变化趋势。 【方法】 采用北京市儿童生命监测网收集的数据,计算出5岁以下儿童先天异常死亡专率、构成比和年龄分布情况。 【结果】 1)北京市5岁以下儿童先天异常死亡专率由2001年的227.1/105下降至2010年的97.1/105;2)北京市城市先天心脏病、神经管畸形、先天愚型均显著下降;农村神经管畸形、先天愚型下降不显著;3)先天异常死亡占5岁以下儿童死亡的比例由2001年的29.2%下降至2010年的23.1%;4)5岁以下儿童先天异常死亡主要发生在婴儿期,尤其是新生儿期。 【结论】 北京市先天发育异常儿童死亡已经成为5岁以下儿童主要死因,需进一步加强农村地区相关疾病的预防水平。
Abstract
【Objective】 To identify the trend of mortality from congenital malformation in children under 5 years old in Beijing from 2001 to 2010. 【Methods】 Data were obtained from the Beijing children mortality surveillance network. A descriptive analysis was performed on birth defect-specific mortality in children under 5 years old(U5MR). 【Results】 1)The birth defect-specific U5MR decrease from 227.1/105 live births in 2001 to 97.1/105 live births in 2010; 2)Congenital heart disease, neural tube defects, Down's syndrome were significantly decreased in urban and neural tube defects, Down's syndrome was not significant decrease in rural; 3)The Proportion of mortality due to major congenital malformation decrease from 29.2% in 2001 to 23.1% in 2010; 4)Mortality from congenital malformation in children under 5 years old mainly in infant, especially in neonate. 【Conclusions】 Congenital malformation has been the leading causes of death in children under 5 years old. Strengthen prevention and reduce congenital malformation of death in rural have been the important work for us.
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参考文献
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[14] Berry RJ, Li Z, Erickson JD, et al. Preventing neural tube defects with folic acid in China[J]. N Engl J Med,1999,341:1485.
[2] Liu S, Joseph KS, Wen SW. Trend in fetal and infant deaths cause by congenital anomalies[J]. Semin Perinatol,2002,26(4):268-276.
[3] 代礼,周光萱,朱军,等.出生缺陷对中国围产儿死亡的影响[J].中华流行病学杂志,2004,25(2):138-141.
[4] The Contribution of Preterm Birth to Infant Mortality Rates in the United States. National center for Health statistics[J]. Pediatrics,2008,121(4):12-20.
[5] Tegnander E, Williams W, Johansen OJ, et al. Prenatal detection of heart defects in a non-selected population of 30,149 fetuses detection rates and outcome[J]. Ultrasound Obstet Gynecol,2006,27(3):252-265.
[6] 何春华,王艳萍,朱军,等.1996-2006年全国5岁以下儿童先天异常死亡流行病学分析[J].四川大学学报,2010;41(2):324-328.
[7] Lee K, Khoshnood B, Chen L, et al. Infant mortality from congenital malformations in the United States,1970-1997[J]. Obstet Gynecol,2001,98(4):620-627.
[8] 刘凯波,潘迎,丁辉.2006年北京市出生缺陷监测数据分析[J].中国优生与遗传杂志,2007,15(6):95-97.
[9] Liu S, Joseph KS, Kramer MS, et al. Relationship of prenatal diagnosis and pregnancy termination to overall infant mortality in Canada[J]. JAMA,2002;287(12):1561-1567.
[10] Wren CO, Sullivan JJ. Survival with congenital heart disease and need for follow-up in adult life[J]. Heart,2001,85(4):438-443.
[11] 张晚霞,朱雪娜.1999-2003年北京市5岁以下儿童先天性心脏病死亡状况分析[J].中国妇幼保健,2005,20(23):3151-3152.
[12] 李竹,李松,王红,等.中国妇女妊娠前后单纯服用叶酸对神经管畸形的预防效果[J].中华医学杂志,2000,80(7):493-498.
[13] 游昭华,赵秀艳,李艳华.2000-2005年福建省主要出生缺陷监测情况分析[J].中国妇幼保健,2006,21:3097-3098.
[14] Berry RJ, Li Z, Erickson JD, et al. Preventing neural tube defects with folic acid in China[J]. N Engl J Med,1999,341:1485.
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