【目的】 建立以人群为基础的胎龄别新生儿出生体重百分位数修匀曲线。 【方法】 对北京市顺义区医院及顺义区妇幼保健院2009年11月1日-2011年1月21日出生的新生儿进行出生体重的标准化测量,选择符合正常母亲标准的单胎活产新生儿出生体重建立数据库。采用偏度-中位数-变异系数法修匀百分位数。将结果与1986-1987年中国15市新生儿体格发育调查进行比较。 【结果】 共5 068例新生儿纳入到研究中,获得了顺义区正常单胎活产新生儿胎龄别出生体重P3,P10,P25,P50,P75,P90,P97修匀曲线。性别差异具统计学意义(P<0.05)。其中小于胎龄儿发生率为9.39%,大于胎龄儿发生率为9.21%。与15市调查比较,在35~43周的胎龄别出生体重均数差异具统计学意义(P<0.05)。 【结论】 本研究建立了北京市顺义区胎龄别新生儿出生体重百分位数修匀曲线,为该地区及其它类似地区评估胎儿生长发育提供了较新的参考依据。
Abstract
【Objective】 To establish population-based smoothed centiles for gestational age specific birthweight of newborns. 【Methods】 All newborns should be taken standard measurement of birthweight during 1 November 2009 to 21 January 2011 in Shunyi District Hospital of Beijing and Shunyi Maternal and Child Health Hospital. The newborns whose mother up to the standards of normal mother were selected to establish database. λ-median-coefficent of variation method was used to smooth the percentile curves. Compare smoothed centiles with neonatal physique growth investigation results of 15 cities of China in 1986-1987. 【Results】 5 068 live births were selected for final analysis. Percentiles at P3, P10, P25, P50, P75, P90, P97 of birthweight were calculated and described and the curves for each gestational-age were successfully smoothed. In general gender differences of birthweight were statistically significant; According to the analysis by gestational age, gender differences in the 38~42 gestational weeks were statistically significant. The incidences of small for gestational age infants and large for gestational age infants are 9.39% and 9.21%. Compared smoothed percentiles with the investigation results of 15 cities, differences of birthweight in 35~43 gestational weeks were statistically significant. 【Conclusions】 Recent percentiles for gestational age specific birthweight of newborns are presented and a current reference is proposed for the local clinicians and researchers to evaluate fetal growth.
关键词
出生体重 /
修匀百分位数 /
新生儿
Key words
birthweight /
smooth pertentiles /
newborn
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参考文献
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基金
比尔梅琳达·盖茨基金会“21世纪胎儿与新生儿生长发育标准研究”(MREC N°:08/H0606/139,UKCRN ID:8454)
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