【目的】 分析新生儿败血症临床表现、实验室检查与围生期高危因素的关系,为临床诊治提供科学依据。 【方法】 以本院67例新生儿败血症患儿为研究组,同期入院的非感染性患儿75例为对照组,对新生儿败血症的临床特点进行回顾性分析。 【结果】 胎膜早破＞18 h、早产儿低体重儿及胎心晚期减速是新生儿败血症的高危因素。败血症患儿体温不升或发热、反应差、腹泻、腹胀、黄疸退而复现或加重、新生儿硬肿及心律失常的发生率明显高于对照组。败血症组患儿外周血WBC>20×10⁹或WBC<5×10⁹、I/T≥0.2、PLT＜100×10⁹及快速C-反应蛋白(C-reactcve protein, CRP)>8 mg/L明显高于对照组,差异有统计学意义。 【结论】 胎心晚期减速、早产儿低出生体重儿及胎膜早破是新生儿败血症的主要高危因素。血培养联合应用外周WBC、I/T、PLT、CRP有助于新生儿败血症的早期诊断。

【Objective】 To analyze the correlation between clinical characteristics, laboratory investigations and perinatal risk factors in neonates with sepsis. 【Method】 Retrospective study was conducted comparing the clinica profile of 67 neonatal sepsis patients and 75 uninfected patients admitted to the hospital 【Results】 Premature rupture of membranes for more than 18 hours, preterm infant low birth weight infant and fetus heart rate late deceleration were risk factors of neonatal sepsis. Theincidence of stagnant temperature or fever, poor response, diarrhea, abdominal distention, relapsing or exacerbating jaundice, neonatal scleredema and arrhythmia were significantly higher in the sepsis group than those in the controll group. The incidence of WBC≥20×10⁹or ≤5×10⁹, the ratio of rhabdocyte/granularcyte I/T cell≥0.2 ,PLT＜100×10⁹,CRP≥8 mg/L in sepsis group were significantly higher than those in the control group. 【Conclusions】 Premature rupture of membranes, preterm infant low birth weight infant and fetus heart rate late deceleration are risk factors of neonatal sepsis. Blood culture combining peripheral WBC, I/T, PLT, CRP may contribute to the early diagnosis of neonatal sepsis.