胞外体与病毒感染的研究进展
- 阎贝贝1 综述,卢宪梅1,邓景畅2 审校
作者信息
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文章历史
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摘要
胞外体(exosome,EXO)起源于多种真核细胞多泡体(multivesicular body,MVBs)的内部小囊泡,MVBs与细胞膜融合后即释放出EXO,其功能决定于来源的细胞。作为细胞间信息传递的新方式,EXO逐渐成为各领域的研究热点。本文就EXO的功能及作用做一综述,着重在病毒感染方面。在病毒感染的过程中,EXO不仅可以作为病毒感染和传播的重要方式,在介导病毒的免疫逃逸和免疫耐受中也扮演了重要角色。
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参考文献
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[13] Lekkerkerker AN, Yvette K, Teunis BH,et al.Viral piracy:HIV-1 targets dendritic cell for transmission[J].Curr HIV Res,2006,4(2):169-176.
[14] Izquierdo-Useros N. Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway[J]. Blood,2009,113(12):2372-2381.
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[16] Flanagan J, Middeldorp J, Sculley T.Localization of the Epstein-Barr virus protein LMP 1 to exosomes[J]. J Gen Virol,2003,84(7):1871-1879.
[17] Klibi J,Niki T, Riedel A,et al. Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells[J]. Blood,2009,113(9):1957-1966.
[18] Mori Y ,Koike M, Moriishi E,et al. Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway[J]. Traffic,2008,9(10):1728-1742.
[19] Walker JD,Maier CL. Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes[J]. J Immunol,2009,182(3):1548-1559.
[20] Jeffrey S. Schorey Sanchita Bhatnagar. Exosome Function: From Tumor Immunology to Pathogen Biology[J]. Traffic,2008,9(6):871-881.
[21] Iero M, Valenti R. Tumour-released exosomes and their implications in cancer immunity[J]. Cell Death Differ,2008,15(1):80-88.
[2] Thery C, Zitvogel L, Amigorena S. Exosomes: composition, biogenesis and function [J].Nat Rev Immunol,2002,2(8):569-579.
[3] Laulagnier K, Motta C, Hamdi S, et al. Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization[J]. Biochem J,2004,380:161-171.
[4] Johnstone RM, Adam M, Pan BT. The fate of the transferrin receptor during maturation of sheep reticulocytes in vitro[J]. Can J Biochem Cell Biol, 1984,62:1246-1254.
[5] Gambim MH, Carmo AO, Marti L, et al. Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction[J]. Crit Care,2007,11:107-109.
[6] Valadi H, Ekstrom K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J]. Nat Cell Biol,2007,9:654-659.
[7] Hao S, Moyana T, Xiang J.Cancer immunotherapy exosome-based vaccines[J]. Cancer Biother Radiopharm, 2007,22(5):692-703.
[8] Andre F, Escudier B, Angevin E, et al. Exosomes for cancer immunotherapy[J]. Ann Oncol,2004,15 (S4):141-144.
[9] Delcayre A,Estelles A,Sperinde J,et al. Exosome Display technology:applications to the development of new diagnostics and therapeutics[J]. Blood Cell Mol Dis,2005,35(2):158-168.
[10] Seow Y, Wood MJ. Biological gene delivery vehicles: beyond viral vectors[J]. Mol Ther,2009,17(5):767-777.
[11] Hoorn EJ, Pisitkun T, Zietse R, et al. Prospects for urinary proteomics: exosomes as a source of urinary biomarkers[J]. Nephrology (Carlton),2005,10:283-290.
[12] Gould SJ,Booth AM,Hildreth JE.The Trojan exosome hypothesis[J]. Proc Natl Acad Sci USA,2003,100(19):10592-10597.
[13] Lekkerkerker AN, Yvette K, Teunis BH,et al.Viral piracy:HIV-1 targets dendritic cell for transmission[J].Curr HIV Res,2006,4(2):169-176.
[14] Izquierdo-Useros N. Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway[J]. Blood,2009,113(12):2372-2381.
[15] Kramer B,Pelchen-Matthews A, Deneka M,et al. HIV interaction with endosomes in macrophages and dendritic cells[J]. Blood Cells Mol Dis,2005, 35(2):136-142.
[16] Flanagan J, Middeldorp J, Sculley T.Localization of the Epstein-Barr virus protein LMP 1 to exosomes[J]. J Gen Virol,2003,84(7):1871-1879.
[17] Klibi J,Niki T, Riedel A,et al. Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells[J]. Blood,2009,113(9):1957-1966.
[18] Mori Y ,Koike M, Moriishi E,et al. Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway[J]. Traffic,2008,9(10):1728-1742.
[19] Walker JD,Maier CL. Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes[J]. J Immunol,2009,182(3):1548-1559.
[20] Jeffrey S. Schorey Sanchita Bhatnagar. Exosome Function: From Tumor Immunology to Pathogen Biology[J]. Traffic,2008,9(6):871-881.
[21] Iero M, Valenti R. Tumour-released exosomes and their implications in cancer immunity[J]. Cell Death Differ,2008,15(1):80-88.
基金
山东省自然科学基金(ZR2009CM075)
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