摘要
【目的】 对联合垂体激素缺乏症(combined pituitary hormone deficiency,CPHD)进行分析,为临床诊治提供参考依据,减少误诊。 【方法】 收集CPHD 20例, 男15例,女5例,进行病史及相关实验室检查的分析。 【结果】 缺乏激素为生长激素(growth hormone,GH)、促肾上腺皮质激素(adrenocorticotropic hormone, ACTH)、促甲状腺激素(thyrotropic-stimulating hormone, TSH)、性激素(gonadotropin,GN)的有3例(15.0％);缺乏激素为GH+ACTH+TSH的有2例(10.0％);GH+GN的有5例(25.0％);GH+TSH的有6例(30.0％);GH+TSH+GN的有2例(10.0％);GH+ACTH 2例(10.0％)。20例均查垂体MRI,其中7例(35.0％)提示有异常。 【结论】 因生长迟缓就诊者应警惕CPHD,及时做其他相关激素的检测,减少误诊。
关键词
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参考文献
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[3] Rodriguez R,Andersen B.Cellular determination in the anterior pituitary gland:PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency[J].Minerva Endocrinol,2003,28(2):123-133.
[4] Vieira TC,Boldarine VT,Abucham J. Molecular analysis of PROP1, PIT1, HESX1, LHX3, and LHX4 shows high frequency of PROP1 mutations in patients with familial forms of combined pituitary hormone deficiency[J].Arq Bras Endocrinol Metabol,2007,51(7):1097-1103.
[5] Reynaud R,Saveanu A. Pituitary hormone deficiencies due to transcription factor gene alterations[J].Growth Horm IGF Res,2004,14(6):442-448.
[2] 颜纯,王慕逖.小儿内分泌学[M]. 2版.北京:人民卫生出版社,2006:105-107.
[3] Rodriguez R,Andersen B.Cellular determination in the anterior pituitary gland:PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency[J].Minerva Endocrinol,2003,28(2):123-133.
[4] Vieira TC,Boldarine VT,Abucham J. Molecular analysis of PROP1, PIT1, HESX1, LHX3, and LHX4 shows high frequency of PROP1 mutations in patients with familial forms of combined pituitary hormone deficiency[J].Arq Bras Endocrinol Metabol,2007,51(7):1097-1103.
[5] Reynaud R,Saveanu A. Pituitary hormone deficiencies due to transcription factor gene alterations[J].Growth Horm IGF Res,2004,14(6):442-448.
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