癫痫儿童相关细胞因子变化及意义
- 李红 综述, 马海燕 审校
作者信息
+
文章历史
+
摘要
细胞因子是由多种细胞产生的具有广泛生物学活性的小分子蛋白质。癫痫作为一种免疫相关性神经系统疾病,其发生发展与细胞因子有着密切关联,诸多细胞因子与其受体结合后可改变中枢神经系统兴奋性,参与癫痫发病过程。笔者将对白细胞介素-2(IL-2) 、白细胞介素-6(IL-6) 、肿瘤坏死因子-α(TNF-α)等具有广泛生物学作用的细胞因子与癫痫的发病机制作一综述,进一步揭示细胞因子在癫痫发病中的作用。
关键词
{{custom_sec.title}}
{{custom_sec.title}}
参考文献
[1] 朱晓琴,雷水生,李正莉,等.细胞因子及免疫抑制剂对大鼠脑内神经递质的影响[J].神经精神医学杂志,2007,20(4):200-202.
[2] Lehtimaki KA, Keramen T, Palmio J, et al. Increased plasma levels of cytokines after seizures in localization-related epilepsy[J]. Acta Neurol Scand,2007,116(4):226-230.
[3] 林忠东,胡鸿文.癫痫患儿的T细胞亚群和白细胞介素2的研究[J].实用临床儿科杂志,1998,13(3):137-138.
[4] 刘智胜,杨立志,王芳琳,等.癫痫患儿血清细胞因子水平变化及其意义[J].中华神经免疫学和神经病学杂志,2002,9(3):132-134.
[5] Wang S, Cheng Q, Malike S, et al. Interleukin-1 beta inhibit sgamma-aminobutyric acid type A[GABA (A)] receptor current inculutured hippocampus neurons[J].J-Pharmacol Exp Ther,2000,292(2):497-504.
[6] 许忠,郑白红,毓明涛,等.白细胞子介素-2及免疫球蛋白治疗小儿难治性癫痫的临床使用[J].中国妇幼保健,2005,20(4):478-480.
[7] 苟鹏.儿童癫痫的免疫学进展[J].现代预防医学杂志,2005,32(4):327-330.
[8] Ravizza T, Rizzi, Perego C, et al. Inflammatory response and glia activation in developing rat hippoeampus after status epilepticus[J]. Epilepsia,2005,46(3):113-117.
[9] 迟光富,曹丽丽,孟祥方,等.癫痫患者血SIL-2R、 TNF-α的测定及其意义[J].临床神经病学杂志,1998,1(4):213-215.
[10] 张振华,庞国象,李国明,等.癫痫患儿血清中TNF-α、IL-6水平的变化及意义[J].广东医学院学报,2003,21(3):232-234.
[11] 牛延献.癫痫大鼠血清和脑组织IL-1b、IL-6和TNF-a水平变化[J].放射免疫学杂志,2005,18(4):256-259.
[12] Lehtimaki KA, Keranen T, Huhtala H, et al. Regulation of IL-6 system in cerebros pinal fluid and serum compartments by seizures: the effect of seizure type and duration[J]. J Neuroimmunol,2004,152(122):121-125.
[13] Alapirtti T, Rinta S, Hulkkonen J, et al. Interleukin-6, interleukin-1 receptor antagonist and interleukin-1beta production in patients with focal epilepsy: A video-EEG study[J]. J Neurol Sci,2009,80(1-2):94-97.
[14] Bauer S, Cepok S, Todorova-Rudolph A, et al. Etiology and site of temporal lobe epilepsy influence postictal cytokine release[J]. Epilepsy Res,2009,86(1):82-88.
[15] Majoie HJ, Rijkers K, Berfelo MW, et al. Vagus nerve stimulation in refractory epilepsy: effects on pro-and anti-inflammatory cytokines in peripheral blood[J]. Neuroimmunomodulation,2011,18(1):52-56.
[16] Shiihara T, Miyashita M, Yoshizumi M, et al. Peripheral lymphocyte subset and serum cytokine profiles of patients with West syndrome[J]. Brain Dev,2010,32(9):695-702.
[17] Asaki K, Matsuo M, Maeda T, et al. characterization of double-stranded RNA-induced gene expression[J]. Pediatr Neurol,2009,41(2):114-118.
[18] De Simoni MG, Perego C, Ravizza T, et al. Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus[J]. Eur J Neurosci,2000,12(7):2623-2633.
[2] Lehtimaki KA, Keramen T, Palmio J, et al. Increased plasma levels of cytokines after seizures in localization-related epilepsy[J]. Acta Neurol Scand,2007,116(4):226-230.
[3] 林忠东,胡鸿文.癫痫患儿的T细胞亚群和白细胞介素2的研究[J].实用临床儿科杂志,1998,13(3):137-138.
[4] 刘智胜,杨立志,王芳琳,等.癫痫患儿血清细胞因子水平变化及其意义[J].中华神经免疫学和神经病学杂志,2002,9(3):132-134.
[5] Wang S, Cheng Q, Malike S, et al. Interleukin-1 beta inhibit sgamma-aminobutyric acid type A[GABA (A)] receptor current inculutured hippocampus neurons[J].J-Pharmacol Exp Ther,2000,292(2):497-504.
[6] 许忠,郑白红,毓明涛,等.白细胞子介素-2及免疫球蛋白治疗小儿难治性癫痫的临床使用[J].中国妇幼保健,2005,20(4):478-480.
[7] 苟鹏.儿童癫痫的免疫学进展[J].现代预防医学杂志,2005,32(4):327-330.
[8] Ravizza T, Rizzi, Perego C, et al. Inflammatory response and glia activation in developing rat hippoeampus after status epilepticus[J]. Epilepsia,2005,46(3):113-117.
[9] 迟光富,曹丽丽,孟祥方,等.癫痫患者血SIL-2R、 TNF-α的测定及其意义[J].临床神经病学杂志,1998,1(4):213-215.
[10] 张振华,庞国象,李国明,等.癫痫患儿血清中TNF-α、IL-6水平的变化及意义[J].广东医学院学报,2003,21(3):232-234.
[11] 牛延献.癫痫大鼠血清和脑组织IL-1b、IL-6和TNF-a水平变化[J].放射免疫学杂志,2005,18(4):256-259.
[12] Lehtimaki KA, Keranen T, Huhtala H, et al. Regulation of IL-6 system in cerebros pinal fluid and serum compartments by seizures: the effect of seizure type and duration[J]. J Neuroimmunol,2004,152(122):121-125.
[13] Alapirtti T, Rinta S, Hulkkonen J, et al. Interleukin-6, interleukin-1 receptor antagonist and interleukin-1beta production in patients with focal epilepsy: A video-EEG study[J]. J Neurol Sci,2009,80(1-2):94-97.
[14] Bauer S, Cepok S, Todorova-Rudolph A, et al. Etiology and site of temporal lobe epilepsy influence postictal cytokine release[J]. Epilepsy Res,2009,86(1):82-88.
[15] Majoie HJ, Rijkers K, Berfelo MW, et al. Vagus nerve stimulation in refractory epilepsy: effects on pro-and anti-inflammatory cytokines in peripheral blood[J]. Neuroimmunomodulation,2011,18(1):52-56.
[16] Shiihara T, Miyashita M, Yoshizumi M, et al. Peripheral lymphocyte subset and serum cytokine profiles of patients with West syndrome[J]. Brain Dev,2010,32(9):695-702.
[17] Asaki K, Matsuo M, Maeda T, et al. characterization of double-stranded RNA-induced gene expression[J]. Pediatr Neurol,2009,41(2):114-118.
[18] De Simoni MG, Perego C, Ravizza T, et al. Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus[J]. Eur J Neurosci,2000,12(7):2623-2633.
基金
青岛市公共领域科技支撑计划资助项目(08-2-1-2-nsh)
-
总访问量
今日访问
在线人数
扫一扫，关注本刊微信公众号
版权所有 © 《中国儿童保健杂志》编辑部
技术支持：北京玛格泰克科技发展有限公司
技术支持：北京玛格泰克科技发展有限公司
/
| 〈 |
|
〉 |