本研究系统梳理了针刺技术治疗孤独症谱系障碍(ASD)的研究进展,涵盖历史渊源、技术变革、假设提出、机制探索、临床验证及成果转化路径。研究回溯至隋代医著中对“惛塞、语迟”等类似重度ASD症状的记载。在现代脑科学框架下,本研究聚焦针刺通过激活外周-中枢神经通路,促进社交神经递质的释放,以改善ASD患者的脑发育。基于前期基础研究发现,团队将传统手针发展为经皮穴位电刺激(TEAS)技术,并采用特定参数刺激对合谷、内关、足三里与三阴交为主的穴位进行标准化治疗方案。多中心临床研究结果显示:在统一行为干预基础上联合TEAS治疗,可显著提高临床疗效,其中“冷漠型/被动型”社交表型患儿获益最为显著。外周血浆催产素(OXT)与精氨酸后叶加压素(AVP)水平的变化,以及多模态脑影像[结构像、静息态功能性磁共振成像(fMRI)、弥散张量成像(DTI)]的一致性变化支持了TEAS通过催产素通路促进感知觉恢复,增强社交动机、降低焦虑情绪的作用假说。临床评估与家长随访数据表明,该疗效具有可重复性。最后,本研究进一步探讨了从分型评估到精准化参数设定、多模态评估体系与家庭可操作化路径的整合意义,提出未来需以更大规模、多中心、分层随机对照试验和多组学整合来验证疗效普适性并进一步阐明分子与网络机制。
Abstract
This study systematically reviews the progress of acupuncture in treating autism spectrum disorder (ASD), covering its historical origins, technological innovations, proposed hypotheses, mechanistic explorations, clinical validation, and pathways for translational research.Tracing back to classical Chinese medical records from the Sui dynasty that described symptoms resembling severe ASD, such as mental obstruction and delayed speech, the study focuses on how acupuncture activates peripheral-to-central neural pathways, promoting the release of pro-social neurotransmitters to improve brain development in individuals with ASD within the framework of modern neuroscience.Building upon preclinical findings, our team developed a transcutaneous electrical acupoint stimulation (TEAS) protocol as a standardized, noninvasive adaptation of traditional acupuncture.The protocol targets four key acupoints with optimized stimulation parameters, including Hegu (LI4), Neiguan (PC6), Zusanli (ST36), and Sanyinjiao (SP6).Multicenter clinical trials demonstrate that integrating TEAS to standardized behavioral therapy significantly enhances therapeutic efficacy, particularly among children with aloof/passive social phenotypes.Consistent changes in peripheral plasma levels of oxytocin (OXT) and arginine vasopressin (AVP), alongside multi-modal brain imaging (structural MRI, resting-state fMRI, and DTI) support the hypothesis that TEAS acts via the OXT pathway to promote sensory integration, enhance social motivation, and reduce anxiety.Clinical assessments and parental follow-up data confirmed the consistent and reproducible benefits.Finally, we further outline a translational roadmap integrating phenotype-based assessment, individualized stimulation parameter optimization, multimodal biomarker systems, and home-based implementation.Large-scale, multicenter, stratified, and multi-omic studies are further warranted to validate generalizability and further elucidate the causal molecular-to-network mechanisms underlying TEAS-mediated neurobehavioral improvement.
关键词
经皮穴位电刺激 /
孤独症谱系障碍 /
社交分型 /
功能性磁共振成像 /
弥散张量成像
Key words
transcutaneous electrical acupoint stimulation /
autism spectrum disorder /
social subtyping /
functional magnetic resonance imaging /
diffusion tensor imaging
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