超重/肥胖儿童并发非酒精性脂肪性肝病的影响因素分析

胡倩; 宁建英

doi:10.11852/zgetbjzz2025-1379

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中国儿童保健杂志 ›› 2026, Vol. 34 ›› Issue (7) : 760-765. DOI: 10.11852/zgetbjzz2025-1379

儿童代谢性疾病

超重/肥胖儿童并发非酒精性脂肪性肝病的影响因素分析

胡倩¹, 宁建英²

作者信息 +

Influencing factors for nonalcoholic fatty liver disease in overweight and obese children

HU Qian¹, NING Jianying²

Author information +

文章历史 +

摘要

目的探讨超重/肥胖儿童并发非酒精性脂肪性肝病(NAFLD)的影响因素,并绘制列线图模型预测患病风险。方法回顾性选取2020年7月—2025年7月石河子大学第一附属医院就医的147例超重/肥胖儿童,将其分为NAFLD组(41例)和非NAFLD组(106例)。采用多因素回归分析探讨超重/肥胖患儿并发NAFLD的影响因素,并通过受试者操作特征(ROC)曲线和R语言构建列线图模型评估其预测价值。结果 NAFLD中超重儿童占7.3%,肥胖儿童占92.7%。单因素分析显示,年龄、超重/肥胖、体质量指数(BMI)、丙氨酸氨基转移酶(ALT)、尿酸(UA)、白细胞计数(WBC)及胰岛素与超重/肥胖儿童合并NAFLD相关(P＜0.05)。多因素logistic回归提示BMI、ALT、WBC是超重/肥胖儿童并发NAFLD的独立相关因素(P＜0.05),ROC曲线提示BMI、WBC、ALT联合预测NAFLD的曲线下面积AUC为0.896(95%CI:0.847~0.946),其灵敏度为97.6%,特异度为68.9%。结论肥胖儿童并发NAFLD的风险高于超重儿童。BMI、ALT、WBC指标越高,NAFLD的患病风险越大,三者联合检测超重/肥胖儿童并发NAFLD具有较高的临床预测价值。

Abstract

Objective To investigate the influencing factors of nonalcoholic fatty liver disease (NAFLD) in overweight and obese children, and to construct a nomogram model for predicting the risk of NAFLD. Methods A total of 147 overweight or obese children who visited The First Affiliated Hospital of Shihezi University from July 2020 to July 2025 were enrolled in this study, and were divided into an NAFLD group (n=41) and a non-NAFLD group (n=106). Multivariate logistic regression analysis was conducted to identify the independent influencing factors for NAFLD. Receiver operating characteristic (ROC) curve analysis was performed, and a nomogram model was constructed using R software to evaluate the predictive value. Results Among the NAFLD cases, 92.7% were obese and 7.3% were overweight. Univariate analysis showed that age, overweight/obesity, body mass index (BMI), alanine aminotransferase (ALT), uric acid (UA), white blood cell count (WBC), and insulin levels were significantly associated with NAFLD (P<0.05). Multivariate logistic regression indicated that BMI, ALT, and WBC were independent related factors for NAFLD (P < 0.05). ROC curve analysis demonstrated that the combined assessment of BMI, WBC, and ALT yielded an area under the curve (AUC) of 0.896 (95%CI: 0.847 - 0.946) for predicting NAFLD, with a sensitivity of 97.6% and a specificity of 68.9%. Conclusions Obese children have a significantly higher risk of NAFLD compared to overweight children. Elevated levels of BMI, ALT, and WBC are associated with an increased risk of NAFLD. The combined assessment of these three indicators has significant predictive value for the development of NAFLD.

导出引用

胡倩, 宁建英. 超重/肥胖儿童并发非酒精性脂肪性肝病的影响因素分析[J]. 中国儿童保健杂志. 2026, 34(7): 760-765 https://doi.org/10.11852/zgetbjzz2025-1379

HU Qian, NING Jianying. Influencing factors for nonalcoholic fatty liver disease in overweight and obese children[J]. Chinese Journal of Child Health Care. 2026, 34(7): 760-765 https://doi.org/10.11852/zgetbjzz2025-1379

中图分类号： R725.75

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