辅助生殖技术受孕儿童健康状况的研究进展

崔一帆; 肖绪武

doi:10.11852/zgetbjzz2025-0857

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中国儿童保健杂志 ›› 2026, Vol. 34 ›› Issue (6) : 680-685. DOI: 10.11852/zgetbjzz2025-0857

综述

辅助生殖技术受孕儿童健康状况的研究进展

崔一帆^1,2, 肖绪武^1,2

作者信息 +

Advances in health status of children conceived through assisted reproductive technology

CUI Yifan^1,2, XIAO Xuwu^1,2

Author information +

文章历史 +

摘要

辅助生殖技术(ART)自1978年问世以来,为治疗不孕不育开创了新时代。目前ART在全球广泛应用,累计已诞生超过1 000万名ART受孕儿童。ART子代的健康状况和生活质量已成为全球医学界及社会各界关注的重要公共卫生问题。本文综述了近年来国内外关于ART受孕儿童健康状况的研究,重点探讨围产期结局、子代代谢状况及行为认知发育是否存在风险。结果显示,目前多数研究认为ART受孕儿童整体健康状况良好。建议推广单胚胎移植以减少多胎妊娠,从源头降低ART儿童围生期并发症及神经发育异常的风险;同时应持续关注其长期健康状况,为优化相关人群的医疗保健提供科学依据。

Abstract

Since the advent of assisted reproductive technology (ART) in 1978, a new era has been opened for infertility management. Currently, ART is widely implemented across the globe, with over 10 million children born to date. The health status and quality of life of ART offspring have evolved into a critical public health concern, drawing extensive attention from the global medical community and society. This paper reviews recent domestic and international research on the health outcomes of ART-conceived children, with a specific focus on three core domains: perinatal outcomes, metabolic status, and potential risks associated with behavioral and cognitive development. Synthesis of the evidence indicates that the overall health status of ART-conceived children is favorable. It is recommended that single embryo transfer be prioritized to reduce multiple pregnancies, thereby mitigating the risks of perinatal complications and neurodevelopmental abnormalities at the source. Meanwhile, sustained surveillance of long-term health trajectories is warranted to facilitate the optimization of healthcare services for this population.

导出引用

崔一帆, 肖绪武. 辅助生殖技术受孕儿童健康状况的研究进展[J]. 中国儿童保健杂志. 2026, 34(6): 680-685 https://doi.org/10.11852/zgetbjzz2025-0857

CUI Yifan, XIAO Xuwu. Advances in health status of children conceived through assisted reproductive technology[J]. Chinese Journal of Child Health Care. 2026, 34(6): 680-685 https://doi.org/10.11852/zgetbjzz2025-0857

中图分类号： R179

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