母乳喂养与自身免疫性疾病关联的机制研究进展

冯丹; 宋彦珺; 覃冬媛; 王凡

doi:10.11852/zgetbjzz2025-0794

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中国儿童保健杂志 ›› 2026, Vol. 34 ›› Issue (4) : 444-448. DOI: 10.11852/zgetbjzz2025-0794

综述

母乳喂养与自身免疫性疾病关联的机制研究进展

冯丹¹, 宋彦珺¹, 覃冬媛¹, 王凡²

作者信息 +

Advances in the mechanisms underlying the association between breastfeeding and autoimmune diseases

FENG Dan¹, SONG Yanjun¹, QIN Dongyuan¹, WANG Fan²

Author information +

文章历史 +

摘要

母乳喂养的健康益处远超基础营养,其降低儿童自身免疫性疾病风险的作用备受关注。母乳中丰富的免疫调节成分,包括抗体、乳铁蛋白、细胞因子以及对新生儿微生物群的塑造,共同促进了免疫系统的成熟与耐受平衡。深入理解母乳喂养的免疫保护角色,不仅为揭示自身免疫性疾病病因提供了新视角,也为制定有效的初级预防公共卫生策略奠定了关键理论基础。本综述系统阐述了母乳喂养对类风湿关节炎、系统性红斑狼疮等自身免疫性疾病的保护作用及相关机制,对未来研究方向进行了展望。

Abstract

The health benefits of breastfeeding extend far beyond basic nutrition, and its potential role in reducing the risk of autoimmune diseases in children has attracted increasing attention.Breast milk contains a wide range of immunomodulatory components, including antibodies, lactoferrin, cytokines, and shapes the neonatal microbiome, collectively promoting immune maturation and the development of balanced immune tolerance.This review examines the protective mechanisms of breastfeeding against autoimmune diseases and outlines future research directions.A deeper understanding of the immune-protective role of breastfeeding will not only provide new insights into the etiology of autoimmune diseases, but also lay an important theoretical foundation for developing effective primary prevention and public health strategies.This review summarizes the protective effects of breastfeeding against autoimmune conditions such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and discusses the underlying mechanisms.

导出引用

冯丹, 宋彦珺, 覃冬媛, 王凡. 母乳喂养与自身免疫性疾病关联的机制研究进展[J]. 中国儿童保健杂志. 2026, 34(4): 444-448 https://doi.org/10.11852/zgetbjzz2025-0794

FENG Dan, SONG Yanjun, QIN Dongyuan, WANG Fan. Advances in the mechanisms underlying the association between breastfeeding and autoimmune diseases[J]. Chinese Journal of Child Health Care. 2026, 34(4): 444-448 https://doi.org/10.11852/zgetbjzz2025-0794

中图分类号： R179

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