维生素D与儿童青少年创伤后骨丢失的相关性研究进展

张金龙; 周宏艳; 赵洪波; 李骏然; 武一恒

doi:10.11852/zgetbjzz2025-0377

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中国儿童保健杂志 ›› 2026, Vol. 34 ›› Issue (4) : 460-464. DOI: 10.11852/zgetbjzz2025-0377

综述

维生素D与儿童青少年创伤后骨丢失的相关性研究进展

张金龙^1,2, 周宏艳², 赵洪波², 李骏然², 武一恒^1,2

作者信息 +

Advances in the relationship between vitamin D and post-traumatic bone loss in children and adolescents

ZHANG Jinlong^1,2, ZHOU Hongyan², ZHAO Hongbo², LI Junran², WU Yiheng^1,2

Author information +

文章历史 +

摘要

创伤后骨丢失是儿童青少年骨折后常见而易被忽视的并发症,可影响峰值骨量并增加远期再骨折风险。维生素D作为骨-肌健康的关键调节因子,可通过调控钙磷代谢、免疫炎症反应及肌肉骨骼力学负荷等途径参与创伤后骨丢失过程。现有临床证据提示,骨折儿童维生素D缺乏/不足普遍存在,并与骨密度下降、再骨折风险增加及骨折愈合延迟等结局相关。本文围绕炎症反应、废用性力学刺激减少以及甲状旁腺激素异常等机制,系统综述维生素D与儿童青少年创伤后骨丢失的关联及其潜在干预价值,并讨论维生素D补充在临床实践中的应用要点。未来仍需开展多中心前瞻性研究与随机对照试验,以明确创伤后维生素D补充的最佳时机、剂量及监测策略。

Abstract

Post-traumatic bone loss is an under-recognized complication following fractures in children and adolescents, which may compromise peak bone mass and increase the long-term risk of refracture.As a key regulator of bone-muscle health, vitamin D may contribute to post-traumatic bone loss through multiple pathways, including modulation of calcium-phosphate metabolism, immune and inflammatory responses, and musculoskeletal mechanical loading.Available clinical evidence suggests that vitamin D deficiency/insufficiency is prevalent among pediatric fracture patients and is associated with reduced bone mineral density, increased refracture risk, and delayed fracture healing.Focusing on mechanisms such as inflammation, reduced disuse-related mechanical stimulation, and parathyroid hormone dysregulation, this review systematically summarizes the association between vitamin D and post-traumatic bone loss in children and adolescents and its potential interventional value, and discusses practical considerations for vitamin D supplementation in clinical practice.Further multicenter prospective studies and randomized controlled trials are warranted to determine the optimal timing, dosage, and monitoring strategy for post-injury vitamin D supplementation.

导出引用

张金龙, 周宏艳, 赵洪波, 李骏然, 武一恒. 维生素D与儿童青少年创伤后骨丢失的相关性研究进展[J]. 中国儿童保健杂志. 2026, 34(4): 460-464 https://doi.org/10.11852/zgetbjzz2025-0377

ZHANG Jinlong, ZHOU Hongyan, ZHAO Hongbo, LI Junran, WU Yiheng. Advances in the relationship between vitamin D and post-traumatic bone loss in children and adolescents[J]. Chinese Journal of Child Health Care. 2026, 34(4): 460-464 https://doi.org/10.11852/zgetbjzz2025-0377

中图分类号： R179

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