物质跨物种传输与肥胖

王瑞; 郭锡熔

doi:10.11852/zgetbjzz2025-0300

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中国儿童保健杂志 ›› 2025, Vol. 33 ›› Issue (10) : 1091-1094. DOI: 10.11852/zgetbjzz2025-0300

儿童代谢性疾病专栏

物质跨物种传输与肥胖

王瑞, 郭锡熔

作者信息 +

Cross-species transmission in obesity

WANG Rui, GUO Xirong

Author information +

文章历史 +

摘要

儿童肥胖已成为21世纪全球公共卫生难题之一。饮食结构的改变不仅导致过量能量摄入,还可通过物质跨物种传输调控人体代谢,是引发儿童肥胖的关键因素。人类与微生物、植物等其他物种在共同进化期间进行频繁的物质跨物种传输,除水平基因转移外,microRNA、同工酶和代谢物可通过肠道菌群、胞外囊泡等媒介进行跨物种传输,实现对人体代谢的跨物种调控。本文对物质跨物种传输的最新进展及肥胖中跨物种传输的最新发现进行系统阐述,以期为儿童肥胖的发生机制解析和防治策略制定提供科学依据与实践指导。

Abstract

Childhood obesity has constituted one of the global public health challenges of the 21st century.Changes in dietary structure not only contribute to excessive energy intake, but also regulate human metabolism through cross-species transmission of signal molecules, which plays an important role in the occurrence of childhood obesity.Humans and other species, such as microorganisms and plants, have frequently engaged in cross-species transmission of signal molecules during co-evolution.In addition to horizontal gene transfer, microRNAs, isoenzymes, and metabolites could be transferred across species through the medium of gut microbiota and extracellular vesicles to achieve cross-species regulation of human metabolism.In this study, the recent progress of cross-species transmission and the latest findings of cross-species transmission in obesity are systematically elaborated, in order to provide scientific basis and practical guidance for exploring mechanism of childhood obesity occurrence and formulating prevention and treatment strategies.

导出引用

王瑞, 郭锡熔. 物质跨物种传输与肥胖[J]. 中国儿童保健杂志. 2025, 33(10): 1091-1094 https://doi.org/10.11852/zgetbjzz2025-0300

WANG Rui, GUO Xirong. Cross-species transmission in obesity[J]. Chinese Journal of Child Health Care. 2025, 33(10): 1091-1094 https://doi.org/10.11852/zgetbjzz2025-0300

中图分类号： R179

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