超级增强子(SE)是基因组中重要的大片段顺式调控元件,通过显著增强基因转录效率发挥基因调控作用。细胞内数百个SE协同调控大量关键基因,其异常活化与糖尿病、炎症和肿瘤等多种疾病的发生密切相关。然而,SE在代谢性疾病中的调控机制研究仍相对滞后。代谢性疾病不仅是多种慢性病的早期诱因,也是肿瘤发生的关键风险因素,被视为疾病发生的“共同土壤”。深入研究SE在代谢性疾病中的作用机制,可为完善疾病防治策略提供科学依据。本文就SE在代谢性疾病中的作用与机制进行综述,以期为开展相关基础研究和开拓临床应用提供依据。
Abstract
Super-enhancers (SEs) are specialized DNA elements that significantly enhance transcriptional efficiency, driving the expression of genes essential for cellular function.Each cell contains hundreds of SEs, which regulate key gene networks.Dysregulation of SEs has been implicated in the aberrant activation of pathogenic genes in diseases such as Alzheimer's, diabetes, inflammation, and cancer.Despite their significance, the role of SEs in metabolism-related diseases remains underexplored.Metabolic disorders often serve as foundational factors in the development of other chronic conditions.Understanding the involvement of SEs in the initiation and progression of metabolic diseases could provide critical insights and inform the development of effective prevention strategies.This review explores the emerging role of SEs in metabolic disorders and their potential as targets for therapeutic intervention.
关键词
超级增强子 /
肥胖 /
转录调控 /
调节元件 /
代谢性疾病
Key words
super-enhancers /
obesity /
transcription /
regulatory elements /
metabolism
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参考文献
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基金
国家重点研发计划(2021YFC2701900;2021YFC2701903);国家自然科学基金项目(82170869)
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