基底体相关蛋白复合体在儿童肥胖及其代谢性疾病中的作用机制

詹舒敏; 傅君芬

doi:10.11852/zgetbjzz2025-0283

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中国儿童保健杂志 ›› 2025, Vol. 33 ›› Issue (10) : 1066-1069. DOI: 10.11852/zgetbjzz2025-0283

儿童代谢性疾病专栏

基底体相关蛋白复合体在儿童肥胖及其代谢性疾病中的作用机制

詹舒敏, 傅君芬

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Mechanisms of Bardet-Biedl syndrome protein complex in childhood obesity and associated metabolic diseases

ZHAN Shumin, FU Junfen

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摘要

基底体相关蛋白复合体(BBSome)是一种由 8 种 Bardet-Biedl 综合征 (BBS) 蛋白组成的复合物,参与纤毛功能。BBSome已成为能量平衡的重要调节器,与肥胖、2型糖尿病和非酒精性脂肪肝等代谢性疾病密切相关。研究表明,BBSome在中枢能量代谢、脂肪酸代谢、葡萄糖稳态、瘦素受体运输等过程中起重要作用。尽管大部分研究集中在成年模型上,但儿童期的BBS症状同样严重,未来应加强对幼年期代谢性疾病的研究,以揭示BBSome在代谢调节中的复杂角色。

Abstract

Bardet-Biedl syndrome protein complex (BBSome) is a complex composed of eight proteins associated with Bardet-Biedl syndrome (BBS) that plays a crucial role in ciliary function.It has emerged as an important regulator of energy balance and is closely linked to metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.Research indicates that BBSome is involved in central energy metabolism, fatty acid metabolism, glucose homeostasis, and the transport of leptin receptors.While most studies have focused on adult models, the symptoms of BBS can be severe in childhood as well.Future research should enhance the understanding of metabolic diseases in early life to elucidate the complex role of BBSome in metabolic regulation.

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Bardet-Biedl syndrome protein complex / Bardet-Biedl syndrome / cilia / childhood obesity / metabolic diseases

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詹舒敏, 傅君芬. 基底体相关蛋白复合体在儿童肥胖及其代谢性疾病中的作用机制[J]. 中国儿童保健杂志. 2025, 33(10): 1066-1069 https://doi.org/10.11852/zgetbjzz2025-0283

ZHAN Shumin, FU Junfen. Mechanisms of Bardet-Biedl syndrome protein complex in childhood obesity and associated metabolic diseases[J]. Chinese Journal of Child Health Care. 2025, 33(10): 1066-1069 https://doi.org/10.11852/zgetbjzz2025-0283

中图分类号： R179

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