婴幼儿照护过程中的微纳米塑料暴露及其毒性效应研究进展

孔晶晶; 陈曲; 赵丽华; 张庆丽; 臧传慧; 赵子矗; 唐婷婷; 祝磊; 肖迪; 李海龙

doi:10.11852/zgetbjzz2025-0222

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中国儿童保健杂志 ›› 2026, Vol. 34 ›› Issue (7) : 798-802. DOI: 10.11852/zgetbjzz2025-0222

综述

婴幼儿照护过程中的微纳米塑料暴露及其毒性效应研究进展

孔晶晶, 陈曲, 赵丽华, 张庆丽, 臧传慧, 赵子矗, 唐婷婷, 祝磊, 肖迪, 李海龙

作者信息 +

Advances in micro/nanoplastics exposure and toxic effectsduring early childhood care

KONG Jingjing, CHEN Qu, ZHAO Lihua, ZHANG Qingli, ZANG Chuanhui, ZHAO Zichu, TANG Tingting, ZHU Lei, XIAO Di, LI Hailong

Author information +

文章历史 +

摘要

微纳米塑料污染问题日益严重,其对人体健康,尤其是婴幼儿健康的潜在威胁备受关注。研究表明,婴幼儿照护过程中普遍存在微纳米塑料,其主要来源包括塑料制品的使用和分解过程。微纳米塑料可通过口腔摄入、皮肤接触和吸入等途径进入儿童体内,可能对儿童的生长发育、免疫系统、神经系统和内分泌系统产生不良影响。本文分析了微纳米塑料污染的来源、暴露途径及毒性效应,并探讨了相应的预防和控制措施,以期为减少儿童微纳米塑料暴露及制定相应的防护策略提供科学依据。

Abstract

The escalating contamination of micro/nanoplastics (MNPs) has raised significant concerns regarding their potential threats to human health, particularly that of infants and toddlers. Evidence suggests that MNPs exposure is widespread during infant and toddler care, with major sources including the use and degradation of plastic-containing products. These particles can enter children's bodies via ingestion, dermal contact and inhalation, potentially exerting adverse effects on their physical growth, as well as their immune, nervous, and endocrine systems.This review analyzes the sources, exposure pathways, and toxicological effects of MNPs contamination. Furthermore, it explores corresponding prevention and control measures to provide a scientific basis for mitigating pediatric MNPs exposure and formulating effective protective strategies.

导出引用

孔晶晶, 陈曲, 赵丽华, 张庆丽, 臧传慧, 赵子矗, 唐婷婷, 祝磊, 肖迪, 李海龙. 婴幼儿照护过程中的微纳米塑料暴露及其毒性效应研究进展[J]. 中国儿童保健杂志. 2026, 34(7): 798-802 https://doi.org/10.11852/zgetbjzz2025-0222

KONG Jingjing, CHEN Qu, ZHAO Lihua, ZHANG Qingli, ZANG Chuanhui, ZHAO Zichu, TANG Tingting, ZHU Lei, XIAO Di, LI Hailong. Advances in micro/nanoplastics exposure and toxic effectsduring early childhood care[J]. Chinese Journal of Child Health Care. 2026, 34(7): 798-802 https://doi.org/10.11852/zgetbjzz2025-0222

中图分类号： R179

参考文献

[1] Zhang Q, Xu EG, Li J, et al. A review of microplastics in table salt, drinking water, and air: Direct human exposure[J]. Environ Sci Technol, 2020, 54(7): 3740-3751.
[2] Saraluck A, Techarang T, Bunyapipat P, et al. Detection of microplastics in human breast milk and its association with changes in human milk bacterial microbiota[J]. J Clin Med, 2024, 13(14): 4029.
[3] Liu LP, Zhang X, Jia PQ, et al. Release of microplastics from breastmilk storage bags and assessment of intake by infants: A preliminary study[J]. Environ Pollut, 2023, 323: 121197.
[4] Kadac-Czapska K, Jutrzenka Trzebiatowska P, Mazurkiewicz M, et al. Isolation and identification of microplastics in infant formulas - A potential health risk for children[J].Food Chem, 2024, 440: 138246.
[5] Wang J, Lee J, Kwon EE, et al. Quantitative analysis of polystyrene microplastic and styrene monomer released from plastic food containers[J]. Heliyon, 2023, 9(5): e15787.
[6] Yadav H, Khan MRH, Quadir M, et al. Cutting boards: An overlooked source of microplastics in human food?[J]. Environ Sci Technol, 2023, 57(22): 8225-8235.
[7] Maurizi L, Iordachescu L, Kirstein IV, et al. Do drinking water plants retain microplastics? An exploratory study using Raman micro-spectroscopy[J]. Heliyon, 2023, 9(6): e17113.
[8] Altunιşιk A. Prevalence of microplastics in commercially sold soft drinks and human risk assessment[J].J Environ Manag, 2023, 336: 117720.
[9] Ding JF, Ju P, Ran Q, et al. Elder fish means more microplastics? Alaska pollock microplastic story in the Bering Sea[J]. Sci Adv, 2023, 9(27): eadf5897.
[10] Luo X, Zhang YL, Kang SC, et al. Atmospheric emissions of microplastics entrained with dust from potential source regions[J]. J Hazard Mater, 2025, 488: 137509.
[11] Myat YN, Kongpran J, Vattanasit U, et al. Suspended airborne microplastics studies in Asia[J]. Environ Chem Lett, 2024, 22(6): 2887-2911.
[12] O'Brien S, Okoffo ED, O'Brien JW, et al. Airborne emissions of microplastic fibres from domestic laundry dryers[J]. Sci Total Environ, 2020, 747: 141175.
[13] Torres-Agullo A, Karanasiou A, Lacorte S. Nasal lavage technique reveals regular inhalation exposure of microplastics, not associated from face mask use[J]. Environ Int, 2023, 178: 108129.
[14] Luo YL, Naidu R, Fang C. Toy building bricks as a potential source of microplastics and nanoplastics[J]. J Hazard Mater, 2024, 471: 134424.
[15] Koutnik VS, Leonard J, El Rassi LA, et al. Children's playgrounds contain more microplastics than other areas in urban parks[J]. Sci Total Environ, 2023, 854: 158866.
[16] Cui TF, Liu K, Zhu LX, et al. Is intravenous infusion an unrecognized route for internal microplastic human exposure? A general assessment[J]. J Hazard Mater, 2024, 480: 135769.
[17] 张雪怡, 张亚昱, 李佳. 微塑料对新生儿健康影响的研究[J]. 中国儿童保健杂志, 2023, 31(4): 399-403.
Zhang XY, Zhang YY, Li J. Research progress in the impact of microplastics on newborn's health[J]. Chin J Child Health Care, 2023, 31(4): 399-403. (in Chinese)
[18] Fabbri L, Garlantézec R, Audouze K, et al. Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study[J]. Environ Int, 2023, 173: 107856.
[19] Wei HQ, Lu SR, Chen MQ, et al. Mechanisms of exacerbation of Th2-mediated eosinophilic allergic asthma induced by plastic pollution derivatives (PPD): A molecular toxicological study involving lung cell ferroptosis and metabolomics[J]. Sci Total Environ, 2024, 946: 174482.
[20] Özsoy S, Gündogdu S, Sezigen S, et al. Presence of microplastics in human stomachs[J]. Forensic Sci Int, 2024, 364: 112246.
[21] 张淑磊, 崔瑞及, 闫灵均, 等. 微塑料在肥胖领域的研究进展[J]. 实用医学杂志, 2024, 40(14): 1908-1914.
Zhang SL, Cui RJ, Yan LJ, et al. Research progress of microplastics in the field of obesity[J]. J Pract Med, 2024, 40(14): 1908-1914. (in Chinese)
[22] Cortés-Arriagada D, Miranda-Rojas S, Camarada MB, et al. The interaction mechanism of polystyrene microplastics with pharmaceuticals and personal care products[J]. Sci Total Environ, 2023, 861: 160632.
[23] Zhou XP, Wang GL, An XY, et al. Polystyrene microplastic particles: In vivo and in vitro ocular surface toxicity assessment[J]. Environ Pollut, 2022, 303: 119126.
[24] Sui YM, Zhang T, Yao XY, et al. Synthesized effects of medium-term exposure to seawater acidification and microplastics on the physiology and energy budget of the thick shell mussel Mytilus coruscus[J]. Environ Pollut, 2022, 308: 119598.
[25] Choi D, Bang J, Kim T, et al.In vitro chemical and physical toxicities of polystyrene microfragments in human-derived cells[J]. J Hazard Mater, 2020, 400: 123308.
[26] Segovia-Mendoza M, Nava-Castro KE, Palacios-Arreola MI, et al. How microplastic components influence the immune system and impact on children health: Focus on cancer[J]. Birth Defects Res, 2020, 112(17): 1341-1361.
[27] Hu JQ, Wang CC, Ma RX, et al. Co-exposure to polyethylene microplastics and house dust mites aggravates airway epithelial barrier dysfunction and airway inflammation via CXCL1 signaling pathway in a mouse model[J]. Int Immunopharmacol, 2025, 146: 113921.
[28] Yang SZ, Guo R, Meng XM, et al. AIM2 participates in house dust mite (HDM)-induced epithelial dysfunctions and ovalbumin (OVA)-induced allergic asthma in infant mice[J]. J Asthma, 2024, 61(5): 479-490.
[29] Xie J, Ji JL, Sun Y, et al. Blood-brain barrier damage accelerates the accumulation of micro- and nanoplastics in the human central nervous system[J]. J Hazard Mater, 2024, 480: 136028.
[30] Chen J, Yan LC, Zhang YP, et al. Maternal exposure to nanopolystyrene induces neurotoxicity in offspring through P53-mediated ferritinophagy and ferroptosis in the rat hippocampus[J]. J Nanobiotechnol, 2024, 22(1): 651.
[31] Marcellus KA, Bugiel S, Nunnikhoven A, et al. Polystyrene nano- and microplastic particles induce an inflammatory gene expression profile in rat neural stem cell-derived astrocytesin vitro[J]. Nanomaterials, 2024, 14(5): 429.
[32] Olisah C, Melymuk L, Audy O, et al. Extremely high levels of PBDEs in children's toys from European markets: Causes and implications for the circular economy[J]. Environ Sci Eur, 2024, 36(1): 183.
[33] Amereh F, Babaei M, Eslami A, et al. The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge[J]. Environ Pollut, 2020, 261: 114158.
[34] Ullah S, Ahmad S, Guo XL, et al. A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals[J]. Front Endocrinol, 2023, 13: 1084236.
[35] Zang SL, Wang F, Ouyang Y, et al. Exposure to polyethylene and polyvinylchloride microplastics caused advanced puberty onset in females through promoting hypothalamic GnRH expression[J]. Ecotoxicol Environ Saf, 2025, 291: 117906.
[36] Chen CZ, Liu F, Quan ST, et al. Microplastics in the bronchoalveolar lavage fluid of Chinese children: Associations with age, city development, and disease features[J]. Environ Sci Technol, 2023, 57(34): 12594-12601.
[37] Wang C, Wu WJ, Pang ZF, et al. Polystyrene microplastics significantly facilitate influenza A virus infection of host cells[J]. J Hazard Mater, 2023, 446: 130617.
[38] Chen YC, Chen KF, Andrew Lin KY, et al. Evaluation of toxicity of polystyrene microplastics under realistic exposure levels in human vascular endothelial EA.hy926 cells[J]. Chemosphere, 2023, 313: 137582.
[39] Lu K, Lai KP, Stoeger T, et al. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology[J]. J Hazard Mater, 2021, 416: 126069.
[40] Cho YS, Seo EU, Hwang KS, et al. Evaluation of size-dependent uptake, transport and cytotoxicity of polystyrene microplastic in a blood-brain barrier (BBB) model[J]. Nano Converg, 2024, 11(1): 40.
[41] Shi YQ, Shi LP, Huang HXY, et al. Analysis of aged microplastics: A review[J]. Environ Chem Lett, 2024, 22(4): 1861-1888.
[42] Choi KM, Mun SH, Shin DJ, et al. The toxic effects of exposure to fibrous and fragmented microplastic in juvenile rockfish based on two omics approach[J]. Chemosphere, 2024, 367: 143541.
[43] Du WT, Xu K, Wang SX, et al. Exposure to polystyrene microplastics with different functional groups: Implications for blood pressure and heart[J]. Environ Pollut, 2025, 372: 126009.
[44] Iizuka A, Mizukoshi A, Noguchi M, et al. Emission fluxes of styrene monomers and other chemicals for products containing expanded polystyrene beads[J]. PLoS One, 2020, 15(10): e0239458.
[45] Zha H, Li SJ, Zhuge AX, et al. Hazard assessment of airborne and foodborne biodegradable polyhydroxyalkanoates microplastics and non-biodegradable polypropylene microplastics[J]. Environ Int, 2025, 196: 109311.