目的 分析血清25-羟维生素D[25-(OH)D]水平与婴儿智力发育的关联性,以评估维生素D对婴儿智力发育的潜在影响。方法 选取2023年11月—2024年9月期间在兰州市妇幼保健院进行体检的205例婴幼儿作为研究对象,回顾性描述其一般情况,并记录3、6、12月龄时的25-(OH)D水平与发育商。通过Spearman相关系数分析二者之间的相关性,运用多元线性逐步回归分析探讨25-(OH)D水平与发育商的独立相关及其与其他因素的共同作用。采用限制性立方样条曲线拟合方法来分析25-(OH)D水平与发育商之间的剂量-反应关系。结果 婴儿在3、6、12月龄时的25-(OH)D水平分别为(29.35±10.21)、(29.97±8.21)、(33.04±6.11)ng/mL,发育商分别为(89.72±7.03)、(90.16±6.38)、(91.08±6.47)分。婴儿在不同月龄阶段的25-(OH)D水平与其发育商均呈显著正相关(r＝0.496、0.474、0.437,P<0.05)。多元线性逐步回归分析进一步证实,血清25-(OH)D是婴儿智力发育的正向影响因素。限制性立方样条拟合曲线分析显示25-(OH)D水平与智力发育商之间存在非线性关系(Pfor overall<0.05,Pnon-linear < 0.05),提示维生素D对智力发育的影响在一定范围内更为显著。结论 兰州市婴儿在不同月龄段的25-(OH)D水平和智力发育水平状况均较为理想,且二者之间存在密切联系。因此,在临床实践中应定期监测血清25-(OH)D水平变化,对于预测和促进儿童智力发育具有重要意义。
Abstract
Objective To analyze the association between serum 25-hydroxyvitamin D [25-(OH)D] levels and intellectual development in infants, and to evaluate the potential influence of vitamin D on their intellectual development. Methods A total of 205 infants who underwent physical examination at the Lanzhou Maternal and Child Health Care Hospital from November 2023 to September 2024 were selected as the study subjects.Their general information was retrospectively described, and the 25-(OH)D levels and developmental quotients (DQ) were recorded at 3, 6, and 12 months of age.The Spearman correlation coefficient was used to analyze the correlation between 25-(OH)D levels and DQ.Multiple linear stepwise regression analysis was employed to explore the independent correlation of 25-(OH)D levels with DQ and the interaction with other factors.Restricted cubic spline curve fitting was used to analyze the dose-response relationship between 25-(OH)D levels and DQ. Results The 25-(OH)D levels of the infants at 3, 6, and 12 months of age were (29.35±10.21) ng/mL, (29.97±8.21) ng/mL, and (33.04±6.11) ng/mL, respectively.Their DQ scores were (89.72±7.03), (90.16±6.38), and (91.08±6.47), respectively.The 25-(OH)D levels at different ages showed a significant positive correlation with DQ (r＝0.496、0.474、0.437,P<0.05).Multiple linear stepwise regression analysis further confirmed that serum 25-(OH)D is a positive influencing factor for intellectual development.The restricted cubic spline curve fitting revealed a non-linear relationship between 25-(OH)D levels and DQ (Pfor overall<0.05, Pnon-linear<0.05), suggesting that the impact of vitamin D on intellectual development was more pronounced within a certain range. Conclusions The 25-(OH)D levels and intellectual development levels of infants in Lanzhou at different months of age are favorable, and there is a close relationship between the two.Therefore, changes in serum 25-(OH)D levels should be regularly monitored in clinical practice, which is important for predicting and promoting intellectual development in children.
关键词
血清25-羟维生素D /
婴儿 /
智力发育 /
相关性
Key words
serum 25-hydroxyvitamin D /
infants /
intellectual development /
correlation
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基金
兰州市卫生健康行业科研项目(A2023024)
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